{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:55:03Z","timestamp":1790567703683,"version":"4.1.0"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"unspecified","delay-in-days":267,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1478951526103563_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Existential distress is common among patients with advanced cancer receiving palliative care and is associated with hopelessness, loss of meaning, spiritual distress, and desire for death. Meaning-centered psychotherapy (MCP) has shown potential in reducing existential suffering and improving psychological well-being in patients with advanced cancer. This article presents a case report describing the application of MCP in a young woman with advanced cancer experiencing depressive symptoms, trauma-related distress, hopelessness, and loss of meaning near the end of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526103563_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report the case of a 24-year-old Vietnamese woman with advanced cancer who was referred for psychological intervention because of severe depressive symptoms, emotional instability, passive wishes for death, and childhood relational trauma. Sixteen psychotherapy sessions were delivered within a multidisciplinary palliative care team. The intervention followed a phased approach, beginning with Trauma-Focused Cognitive Behavioral Therapy-informed stabilization and subsequently transitioning to adapted Individual MCP. Clinical outcomes were evaluated using the Depression Anxiety Stress Scale-21, Beck Depression Inventory-II, and qualitative clinical observations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526103563_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Psychological reassessment demonstrated marked reductions in depression, anxiety, and stress, accompanied by improved emotional regulation, interpersonal functioning, illness acceptance, and relational reconnection. As her condition deteriorated, psychotherapy increasingly emphasized spiritual reflection, reconciliation, and preparation for death. Before death, she reaffirmed her Christian faith, received baptism, and fulfilled her wish for a Protestant funeral ceremony.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526103563_sec4d\">\n                    <jats:title>Significance of results<\/jats:title>\n                    <jats:p>This case illustrates the feasibility of integrating adapted MCP within multidisciplinary palliative care to address existential distress, facilitate meaning reconstruction, support spiritual integration, and promote end-of-life preparation in patients with advanced cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1478951526103563","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:52:03Z","timestamp":1790319123000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Meaning-centered psychotherapy for existential distress in advanced cancer: A culturally informed case report from Vietnam"],"prefix":"10.1017","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9583-5605","authenticated-orcid":false,"given":"Phuong Linh","family":"Hua","sequence":"first","affiliation":[{"name":"Spring Hospice Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Anh Thu","family":"Nguy\u1ec5n","sequence":"additional","affiliation":[{"name":"University of Social Sciences and Humanities (USSH), Vietnam National University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"S1478951526103563_ref2","volume-title":"Meaning-Centered Group Psychotherapy for Patients with Advanced Cancer: A Treatment Manual","author":"Breitbart","year":"2014"},{"key":"S1478951526103563_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(01)00084-3"},{"key":"S1478951526103563_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.22.2907"},{"key":"S1478951526103563_ref8","volume-title":"Man\u2019s Search for Meaning","author":"Frankl","year":"2006"},{"key":"S1478951526103563_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1556"},{"key":"S1478951526103563_ref10","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2014.9427"},{"key":"S1478951526103563_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.05.010"},{"key":"S1478951526103563_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3417"},{"key":"S1478951526103563_ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.2517"},{"key":"S1478951526103563_ref6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.2198"},{"key":"S1478951526103563_ref11","doi-asserted-by":"publisher","DOI":"10.1177\/0269216316651570"},{"key":"S1478951526103563_ref9","doi-asserted-by":"publisher","DOI":"10.1177\/082585970101700103"}],"container-title":["Palliative and Supportive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1478951526103563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:54:59Z","timestamp":1790564099000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1478951526103563\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":12,"alternative-id":["S1478951526103563"],"URL":"https:\/\/doi.org\/10.1017\/s1478951526103563","relation":{},"ISSN":["1478-9515","1478-9523"],"issn-type":[{"value":"1478-9515","type":"print"},{"value":"1478-9523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press or the rights holder(s) must be obtained prior to any commercial use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e235"}}