{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:48:19Z","timestamp":1792057699542,"version":"4.4.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"unspecified","delay-in-days":287,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1478951526103873_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Studies show that cancer patients consider place of death (POD) an important factor influencing quality of life (QoL) at the end of life. The objectives of this study were to identify characteristics of real-world non-small cell lung cancer (NSCLC) patients based on POD and investigate how changes in health-related QoL (HRQoL) relate to POD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526103873_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Newly updated data from a prospective single-center Danish cohort (NCT03870464) of patients with NSCLC who initiated immune checkpoint inhibitors (ICI) as monotherapy between April 1, 2018, and April 30, 2021, at the Department of Oncology, Odense University Hospital, were used for analyses. Clinical data were retrieved from electronic patient records. This included POD, which was categorized as\n                      <jats:italic>home, hospice\/palliative care unit<\/jats:italic>\n                      , or\n                      <jats:italic>hospital<\/jats:italic>\n                      . HRQoL questionnaires were completed by patients prospectively at baseline and at predefined timepoints during treatment with ICI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526103873_sec3c\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A higher percentage (63.6%) of patients dying at home were male, and a higher percentage dying in a hospice\/palliative care unit were female (63%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.041). Patients with hospital as POD had a statistically higher Global health status\/QoL (GHS\/QoL) at baseline (75.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.034). Patients with home or hospice\/palliative care unit as POD reported improved QoL during treatment with ICI, as opposed to patients with hospital as POD who had unchanged self-assessed QoL scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526103873_sec4d\">\n                    <jats:title>Significance of results<\/jats:title>\n                    <jats:p>Sex, baseline GHS\/QoL, and change in HRQoL during treatment with ICI differed between patients based on POD. The predictive value of this is unknown, suggesting the need for further research on this topic, as it remains clinically relevant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1478951526103873","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:21:50Z","timestamp":1792056110000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Patient characteristics and quality of life in relation to place of death in lung cancer patients treated with immunotherapy"],"prefix":"10.1017","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9587-682X","authenticated-orcid":false,"given":"Amalie","family":"Rasmussen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00ey0ed83","id-type":"ROR","asserted-by":"publisher"}],"name":"Odense University Hospital"},{"id":[{"id":"https:\/\/ror.org\/03yrrjy16","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Southern Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte Holm","family":"Land","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00ey0ed83","id-type":"ROR","asserted-by":"publisher"}],"name":"Odense University Hospital"},{"name":"University of Southern Denmark, Department of Clinical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren","family":"M\u00f6ller","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yrrjy16","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Southern Denmark Department of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia Krause","family":"M\u00f8ller","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00ey0ed83","id-type":"ROR","asserted-by":"publisher"}],"name":"Odense University Hospital"},{"name":"University of Southern Denmark, Department of Clinical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Meklenborg","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00ey0ed83","id-type":"ROR","asserted-by":"publisher"}],"name":"Odense University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte","family":"Bj\u00f8rnhart","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00ey0ed83","id-type":"ROR","asserted-by":"publisher"}],"name":"Odense University Hospital"},{"id":[{"id":"https:\/\/ror.org\/00ey0ed83","id-type":"ROR","asserted-by":"publisher"}],"name":"Odense Universitetshospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"S1478951526103873_ref28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000678"},{"key":"S1478951526103873_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.10.005"},{"key":"S1478951526103873_ref5","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2023.2238544"},{"key":"S1478951526103873_ref13","unstructured":"EuroQol Research Foundation, EQ-5D-5L User Guide (2019) 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Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press or the rights holder(s) must be obtained prior to any commercial use and\/or adaptation of the article.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e271"}}