{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:49:40Z","timestamp":1791528580733,"version":"4.3.4"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"unspecified","delay-in-days":281,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1478951526103964_sec1a\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with cancer on palliative treatment often have dynamic and multidimensional symptoms like pain, fatigue, anorexia, cognitive changes, and emotional distress that significantly impact functional capacity and quality of life. Traditional symptom management is largely reactive, based on patient self-report or clinician recognition after deterioration, leading to delayed interventions and avoidable suffering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526103964_sec2b\">\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this systematic review was to review the evidence on nurse-led predictive symptom-management strategies in oncology palliative care, with a focus on the role of laboratory biomarkers and clinical judgment in the early detection of deterioration and better quality of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526103964_sec3c\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was performed in PubMed, CINAHL, Scopus, Embase, and the Cochrane Library through November 2025. Keywords included \u201cnurse-led,\u201d \u201cpredictive symptom management,\u201d \u201cpalliative care,\u201d \u201concology,\u201d \u201cbiomarkers,\u201d and \u201cclinical judgment.\u201d Both qualitative and quantitative studies were included in the review. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram: 1,482 records identified, 346 duplicates removed, 1,136 screened, 128 full texts assessed, and 14 eligible studies selected based on PRISMA 2020 statements. The review protocol was registered in advance in the International Prospective Register of Systematic Reviews (PROSPERO; Registration No. CRD420261432500).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526103964_sec4d\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The included studies (Randomised Controlled Trials (RCTs), cohorts, modeling studies, and telehealth interventions) demonstrated that biomarkers such as C-reactive protein, neutrophil\u2013lymphocyte ratio, albumin, ferritin, and electrolytes predicted symptom exacerbation and clinical decline. Nurse-led approaches including biomarkers with clinical assessment improved the management of symptoms, decreased emergency department visits, and improved continuity of care. Predictive models were promising but limited in clinical integration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526103964_sec5e\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nurse-led predictive approaches support a shift from reactive to proactive palliative care. Further research is needed to embed predictive tools into routine practice and to validate their effectiveness in real-world settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1478951526103964","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:53:11Z","timestamp":1791525191000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Nursing-led predictive symptom management in oncology palliative care: Using laboratory indicators and clinical judgment to improve patient quality of life: A systematic review"],"prefix":"10.1017","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8192-0017","authenticated-orcid":false,"given":"Ateya Megahed","family":"Ibrahim","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04jt46d36","id-type":"ROR","asserted-by":"publisher"}],"name":"Prince Sattam Bin Abdulaziz University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5689-7758","authenticated-orcid":false,"given":"Donia Elsaid Fathi","family":"Zaghamir","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04jt46d36","id-type":"ROR","asserted-by":"publisher"}],"name":"Prince Sattam Bin Abdulaziz University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humood","family":"AlShamrany","sequence":"additional","affiliation":[{"name":"College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"S1478951526103964_ref15","unstructured":"Jerop, M Nurse\u2019s experiences in providing end-of-life care for the elderly. 2025."},{"key":"S1478951526103964_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2024.01.009"},{"key":"S1478951526103964_ref1","first-page":"69","article-title":"Confidence and educational needs of palliative care in oncology nurses caring for patients with advanced cancer in a teaching hospital: A cross-sectional study","volume":"12","author":"Almutairi","year":"2023","journal-title":"American Journal of Nursing Science"},{"key":"S1478951526103964_ref32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-71488-y"},{"key":"S1478951526103964_ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s12904-025-01785-4"},{"key":"S1478951526103964_ref27","article-title":"Biomarkers for early detection of carcinogenesis","volume":"23","author":"Rettori","year":"2024","journal-title":"Journal of 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laboratory professionals, nurses, pharmacists in patient care","volume":"7","author":"Hijazi","year":"2024","journal-title":"Journal of the International Crisis Risk Communications in Research"},{"key":"S1478951526103964_ref24","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.111142"},{"key":"S1478951526103964_ref26","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2022.0008"},{"key":"S1478951526103964_ref6","doi-asserted-by":"publisher","DOI":"10.1177\/1460458220987580"},{"key":"S1478951526103964_ref33","first-page":"125","volume-title":"Middle Range Theory for 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Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e257"}}