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Here we explore developmental interactions between ORN axons and AN glial cells. During early stages in AN glial-cell migration, glial cells are highly dye coupled, dividing glia are readily found in the nerve and AN glial cells label strongly for glutamine synthetase. By the end of this period, dye-coupling is rare, glial proliferation has ceased, glutamine synthetase labeling is absent, and glial processes have begun to extend to enwrap bundles of axons, a process that continues throughout the remainder of metamorphic development. Whole-cell and perforated-patch recordings<jats:italic>in vivo<\/jats:italic>from AN glia at different stages of network formation revealed two potassium currents and an R-like calcium current. Chronic<jats:italic>in vivo<\/jats:italic>exposure to the R-type channel blocker SNX-482 halted or greatly reduced AN glial migration. Chronically blocking spontaneous Na-dependent activity by injection of tetrodotoxin reduced the glial calcium current implicating an activity-dependent interaction between ORNs and glial cells in the development of glial calcium currents.<\/jats:p>","DOI":"10.1017\/s1740925x11000081","type":"journal-article","created":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T08:19:11Z","timestamp":1316593151000},"page":"245-261","source":"Crossref","is-referenced-by-count":6,"title":["Development of a glial network in the olfactory nerve: role of calcium and neuronal activity"],"prefix":"10.1017","volume":"6","author":[{"given":"Mounir A.","family":"Koussa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie P.","family":"Tolbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne 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