{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:16:16Z","timestamp":1793481376181,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":337,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1017\/s1751731119001605","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T06:55:07Z","timestamp":1563951307000},"page":"330-338","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Review: Endocrine pathways to regulate calcium homeostasis around parturition and the prevention of hypocalcemia in periparturient dairy cows"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2729-0434","authenticated-orcid":false,"given":"L.E.","family":"Hern\u00e1ndez-Castellano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.L.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Bruckmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1017\/S1751731119001605_r1","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1210\/en.2010-0033","article-title":"Evidence for a role of prolactin in calcium homeostasis: regulation of intestinal transient receptor potential vanilloid type 6, intestinal calcium absorption, and the 25-hydroxyvitamin D(3) 1alpha hydroxylase gene by prolactin","volume":"151","author":"Ajibade","year":"2010","journal-title":"Endocrinology"},{"key":"10.1017\/S1751731119001605_r2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1530\/eje.0.1370402","article-title":"Calcium-regulating hormones and parathyroid hormone-related peptide in normal human pregnancy and postpartum: a longitudinal study","volume":"137","author":"Ardawi","year":"1997","journal-title":"European Journal of Endocrinology"},{"key":"10.1017\/S1751731119001605_r3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1139\/Y07-041","article-title":"Prolactin is an important regulator of intestinal calcium transport","volume":"85","author":"Charoenphandhu","year":"2007","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"10.1017\/S1751731119001605_r4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1139\/Y08-037","article-title":"Prolactin decreases expression of Runx2, osteoprotegerin, and RANKL in primary osteoblasts derived from tibiae of adult female rats","volume":"86","author":"Charoenphandhu","year":"2008","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"10.1017\/S1751731119001605_r5","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4102\/jsava.v88i0.1457","article-title":"A study of the incidence of milk fever in Jersey and Holstein cows at a dairy farm in Beatrice, Zimbabwe","volume":"88","author":"Chiwome","year":"2017","journal-title":"Journal of the South African Veterinary Association"},{"key":"10.1017\/S1751731119001605_r6","doi-asserted-by":"crossref","first-page":"a003251","DOI":"10.1101\/cshperspect.a003251","article-title":"Molecular mechanisms guiding embryonic mammary gland development","volume":"2","author":"Cowin","year":"2010","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"10.1017\/S1751731119001605_r7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tvjl.2007.12.029","article-title":"Milk fever in dairy cows: a review of pathophysiology and control principles","volume":"176","author":"DeGaris","year":"2008","journal-title":"Veterinary Journal"},{"key":"10.1017\/S1751731119001605_r8","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.3168\/jds.2010-3092","article-title":"Effect of prepartum anionic supplementation on periparturient feed intake, health, and milk production","volume":"93","author":"DeGroot","year":"2010","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r9","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/BF03546643","article-title":"Prevention of Milk Fever (Hypocalcemic Paresis Puerperalis) by Dietary Salt Supplements","volume":"16","author":"Dishington","year":"1975","journal-title":"Acta Veterinaria Scandinavica"},{"issue":"suppl. 1","key":"10.1017\/S1751731119001605_r10","first-page":"5","volume":"3","author":"Ender","year":"1962","journal-title":"Acta Veterinaria Scandinavica"},{"issue":"suppl. 1","key":"10.1017\/S1751731119001605_r11","first-page":"184","article-title":"Breed affects tissue vitamin D receptor concentration in periparturient dairy cows: a milk fever risk factor","volume":"78","author":"Goff","year":"1995","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tvjl.2007.12.020","article-title":"The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows","volume":"176","author":"Goff","year":"2008","journal-title":"Veterinary Journal"},{"key":"10.1017\/S1751731119001605_r13","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.2527\/jas2017.1673","article-title":"Triennial lactation symposium\/bolfa: serotonin and the regulation of calcium transport in dairy cows","volume":"95","author":"Hernandez","year":"2017","journal-title":"Journal of Animal Science"},{"key":"10.1017\/S1751731119001605_r14","doi-asserted-by":"crossref","first-page":"E1009","DOI":"10.1152\/ajpendo.00666.2011","article-title":"Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals","volume":"302","author":"Hernandez","year":"2012","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"key":"10.1017\/S1751731119001605_r15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1677\/JOE-09-0187","article-title":"The bovine mammary gland expresses multiple functional isoforms of serotonin receptors","volume":"203","author":"Hernandez","year":"2009","journal-title":"Journal of Endocrinology"},{"key":"10.1017\/S1751731119001605_r16","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.3168\/jds.2016-12441","article-title":"Endocrine and metabolic changes in transition dairy cows are affected by prepartum infusions of a serotonin precursor","volume":"100","author":"Hern\u00e1ndez-Castellano","year":"2017","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r17","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3168\/jds.2017-13501","article-title":"Supplementation of colostrum and milk with 5-hydroxy-l-tryptophan affects immune factors but not growth performance in newborn calves","volume":"101","author":"Hern\u00e1ndez-Castellano","year":"2017","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r18","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.3168\/jds.2016-11638","article-title":"Increased serum serotonin improves parturient calcium homeostasis in dairy cows","volume":"100","author":"Hern\u00e1ndez-Castellano","year":"2017","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3168\/jds.S0022-0302(55)94939-0","article-title":"Studies on milk fever in dairy cows. 4. Prevention by short-time, prepartum feeding of massive doses of vitamin-D","volume":"38","author":"Hibbs","year":"1955","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r20","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.3168\/jds.S0022-0302(94)77140-X","article-title":"Calcium and vitamin D metabolism in the dairy cow","volume":"77","author":"Horst","year":"1994","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1080\/09712119.2018.1563548","article-title":"Effects of dietary Zeolite supplementation on milk yield and composition and blood minerals status in lactating dairy cows","volume":"47","author":"Khachlouf","year":"2019","journal-title":"Journal of Applied Animal Research"},{"key":"10.1017\/S1751731119001605_r22","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.ecl.2011.08.002","article-title":"Calcium and bone metabolism disorders during pregnancy and lactation","volume":"40","author":"Kovacs","year":"2011","journal-title":"Endocrinology and Metabolism Clinics of North America"},{"key":"10.1017\/S1751731119001605_r23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev-nutr-071811-150742","article-title":"The role of vitamin D in pregnancy and lactation: insights from animal models and clinical studies","volume":"32","author":"Kovacs","year":"2012","journal-title":"Annual Review of Nutrition"},{"key":"10.1017\/S1751731119001605_r24","first-page":"832","article-title":"Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation","volume":"18","author":"Kovacs","year":"1997","journal-title":"Endocrine Reviews"},{"key":"10.1017\/S1751731119001605_r25","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3168\/jds.2009-3025","article-title":"Effects of prepartum dietary calcium level on calcium and magnesium metabolism in periparturient dairy cows","volume":"94","author":"Kronqvist","year":"2011","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r26","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1017\/S175173111200033X","article-title":"Relationship between incidence of milk fever and feeding of minerals during the last 3 weeks of gestation","volume":"6","author":"Kronqvist","year":"2012","journal-title":"Animal"},{"key":"10.1017\/S1751731119001605_r27","doi-asserted-by":"crossref","first-page":"e110190","DOI":"10.1371\/journal.pone.0110190","article-title":"Peripheral serotonin regulates maternal calcium trafficking in mammary epithelial cells during lactation in mice","volume":"9","author":"Laporta","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1017\/S1751731119001605_r28","doi-asserted-by":"crossref","first-page":"5146","DOI":"10.3168\/jds.2013-6718","article-title":"Short communication: Circulating serotonin (5-HT) concentrations on day 1 of lactation as a potential predictor of transition-related disorders","volume":"96","author":"Laporta","year":"2013","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r29","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.3168\/jds.2016-12221","article-title":"Effects of prepartum dietary cation-anion difference on aspects of peripartum mineral and energy metabolism and performance of multiparous Holstein cows","volume":"100","author":"Leno","year":"2017","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r30","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.beem.2011.05.008","article-title":"Calcemic actions of vitamin D: effects on the intestine, kidney and bone","volume":"25","author":"Lieben","year":"2011","journal-title":"Best Practice & Research: Clinical Endocrinology & Metabolism"},{"key":"10.1017\/S1751731119001605_r31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1385\/ENDO:20:1-2:163","article-title":"Bone calcium turnover, formation, and resorption in bromocriptine- and prolactin-treated lactating rats","volume":"20","author":"Lotinun","year":"2003","journal-title":"Endocrine"},{"key":"10.1017\/S1751731119001605_r32","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.3168\/jds.2017-13740","article-title":"Effects of prepartum dietary cation-anion difference and source of vitamin D in dairy cows: health and reproductive responses","volume":"101","author":"Martinez","year":"2018","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S002202991600039X","article-title":"Pre-calving feeding of rumen-protected rice bran to multiparous dairy cows improves recovery of calcaemia after calving","volume":"83","author":"Martin-Tereso","year":"2016","journal-title":"Journal of Dairy Research"},{"key":"10.1017\/S1751731119001605_r34","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1534-5807(04)00022-X","article-title":"Serotonin regulates mammary gland development via an autocrine-paracrine loop","volume":"6","author":"Matsuda","year":"2004","journal-title":"Developmental Cell"},{"key":"10.1017\/S1751731119001605_r35","first-page":"351","article-title":"Parturient paresis and hypocalcemia in ruminant livestock","volume":"4","author":"Oetzel","year":"1988","journal-title":"Veterinary Clinics of North America: Food Animal Practice"},{"key":"10.1017\/S1751731119001605_r36","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.2527\/jas2017.1834","article-title":"Prepartum daylight exposure increases serum calcium concentrations in dairy cows at the onset of lactation","volume":"95","author":"\u00d6z\u00e7elik","year":"2017","journal-title":"Journal of Animal Science"},{"key":"10.1017\/S1751731119001605_r37","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.tvjl.2010.03.025","article-title":"Prevalence of subclinical hypocalcemia in dairy herds","volume":"188","author":"Reinhardt","year":"2011","journal-title":"Veterinary Journal"},{"key":"10.1017\/S1751731119001605_r38","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.3168\/jds.S0022-0302(06)72354-2","article-title":"Periparturient climatic, animal, and management factors influencing the incidence of milk Fever in grazing systems","volume":"89","author":"Roche","year":"2006","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r39","first-page":"135","article-title":"The influence of pregnancy and lactation on maternal bone health: a systematic review","volume":"8","author":"Salari","year":"2014","journal-title":"Journal of Family and Reproductive Health"},{"key":"10.1017\/S1751731119001605_r40","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.3168\/jds.2017-13938","article-title":"Interaction of 5-hydroxy-L-tryptophan and negative dietary cation-anion difference on calcium homeostasis in multiparous peripartum dairy cows","volume":"101","author":"Slater","year":"2018","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r41","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.3168\/jds.S0022-0302(02)74259-8","article-title":"The effect of zeolite A supplementation in the dry period on periparturient calcium, phosphorus, and magnesium homeostasis","volume":"85","author":"Thilsing-Hansen","year":"2002","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1751-0147-43-1","article-title":"Milk fever control principles: a review","volume":"43","author":"Thilsing-Hansen","year":"2002","journal-title":"Acta Veterinaria Scandinavica"},{"key":"10.1017\/S1751731119001605_r43","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/jbmr.5650100614","article-title":"Serum pyridinoline as a specific marker of collagen breakdown and bone metabolism in hemodialysis-patients","volume":"10","author":"Urena","year":"1995","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1017\/S1751731119001605_r44","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1084\/jem.20031454","article-title":"Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist","volume":"199","author":"van Bezooijen","year":"2004","journal-title":"Journal of Experimental Medicine"},{"key":"10.1017\/S1751731119001605_r45","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.3168\/jds.2016-12506","article-title":"Use of calcitriol to maintain postpartum blood calcium and improve immune function in dairy cows","volume":"100","author":"Vieira-Neto","year":"2017","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1530\/JOE-16-0038","article-title":"Elevation of circulating serotonin improves calcium dynamics in the peripartum dairy cow","volume":"230","author":"Weaver","year":"2016","journal-title":"Journal of Endocrinology"},{"key":"10.1017\/S1751731119001605_r47","doi-asserted-by":"crossref","first-page":"e0184939","DOI":"10.1371\/journal.pone.0184939","article-title":"Elevating serotonin pre-partum alters the Holstein dairy cow hepatic adaptation to lactation","volume":"12","author":"Weaver","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1017\/S1751731119001605_r48","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.3168\/jds.2014-9188","article-title":"Effect of feeding 25-hydroxyvitamin D3 with a negative cation-anion difference diet on calcium and vitamin D status of periparturient cows and their calves","volume":"98","author":"Weiss","year":"2015","journal-title":"Journal of Dairy Science"},{"key":"10.1017\/S1751731119001605_r49","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1017\/S002202991400020X","article-title":"Differences in peripartal plasma parameters related to calcium homeostasis of dairy sheep and goats in comparison with cows","volume":"81","author":"Wilkens","year":"2014","journal-title":"Journal of Dairy Research"},{"key":"10.1017\/S1751731119001605_r50","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/bonekey.2012.229","article-title":"Osteocytic osteolysis: time for a second look?","volume":"1","author":"Wysolmerski","year":"2012","journal-title":"Bonekey Reports"}],"container-title":["Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751731119001605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751731119001605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1751731119001605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:38:55Z","timestamp":1761694735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751731119001605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"alternative-id":["S1751731119001605"],"URL":"https:\/\/doi.org\/10.1017\/s1751731119001605","relation":{},"ISSN":["1751-7311"],"issn-type":[{"value":"1751-7311","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Review: Endocrine pathways to regulate calcium homeostasis around parturition and the prevention of hypocalcemia in periparturient dairy cows","name":"articletitle","label":"Article Title"},{"value":"Animal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1017\/S1751731119001605","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 The Animal Consortium. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}