{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:20:26Z","timestamp":1788916826487,"version":"build-2803163510"},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p>The partial contributions of reductions in fetal nutrition and oxygenation to slow fetal growth and a developmental origin of cardiovascular disease remain unclear. By combining high altitude with the chick embryo model, we have previously isolated the direct effects of high-altitude hypoxia on growth. This study isolated the direct effects of high-altitude hypoxia on cardiovascular development. Fertilized eggs from sea-level or high-altitude hens were incubated at sea level or high altitude. Fertilized eggs from sea-level hens were also incubated at high altitude with oxygen supplementation. High altitude promoted embryonic growth restriction, cardiomegaly and aortic wall thickening, effects which could be prevented by incubating eggs from high-altitude hens at sea level or by incubating eggs from sea-level hens at high altitude with oxygen supplementation. Embryos from high-altitude hens showed reduced effects of altitude incubation on growth restriction but not on cardiovascular remodeling. The data show that: (1) high-altitude hypoxia promotes embryonic cardiac and vascular disease already evident prior to hatching and that this is associated with growth restriction; (2) the effects can be prevented by increased oxygenation; and (3) the effects are different in embryos from sea-level or high-altitude hens.<\/jats:p>","DOI":"10.1017\/s2040174409990043","type":"journal-article","created":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T15:38:01Z","timestamp":1254411481000},"page":"60-66","source":"Crossref","is-referenced-by-count":30,"title":["Cardiac and vascular disease prior to hatching in chick embryos incubated at high altitude"],"prefix":"10.1017","volume":"1","author":[{"given":"C. E.","family":"Salinas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Villena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"Camm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"Tuckett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Weerakkody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. D.","family":"Kane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Shelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. B. P.","family":"Wooding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Quy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Giussani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,10,1]]},"reference":[{"key":"S2040174409990043_ref32","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.084889"},{"key":"S2040174409990043_ref35","doi-asserted-by":"publisher","DOI":"10.1159\/000242515"},{"key":"S2040174409990043_ref13","doi-asserted-by":"publisher","DOI":"10.4159\/harvard.9780674428614"},{"key":"S2040174409990043_ref3","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2001145"},{"key":"S2040174409990043_ref28","first-page":"379","article-title":"Studies on experimental growth retardation in sheep. The effect of removal of endometrial caruncles on fetal size and metabolism","volume":"1","author":"Robinson","year":"1979","journal-title":"J Dev Physiol"},{"key":"S2040174409990043_ref27","first-page":"43","article-title":"Autonomic control of heart rate differs with electrocortical activity and chronic hypoxaemia in fetal lambs","volume":"14","author":"Walker","year":"1990","journal-title":"J Dev Physiol"},{"key":"S2040174409990043_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2008.07.013"},{"key":"S2040174409990043_ref21","first-page":"292","volume-title":"Statistical Methods in Medical Research","author":"Armitage","year":"1994"},{"key":"S2040174409990043_ref23","first-page":"309","article-title":"Effects of reducing uterine blood flow on fetal blood flow distribution and oxygen delivery","volume":"15","author":"Jensen","year":"1991","journal-title":"J Dev Physiol"},{"key":"S2040174409990043_ref39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005155"},{"key":"S2040174409990043_ref36","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.23.2892"},{"key":"S2040174409990043_ref19","volume-title":"Respiratory Physiology. The Essentials","author":"West","year":"2004"},{"key":"S2040174409990043_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2008.04975.x"},{"key":"S2040174409990043_ref38","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00611.2003"},{"key":"S2040174409990043_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018070-00002"},{"key":"S2040174409990043_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4004(88)90040-9"},{"key":"S2040174409990043_ref41","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.1242\/dev.125.24.4931","article-title":"Pharmacological inactivation of the endothelin type A receptor in the early chick embryo: a model of mispatterning of the branchial arch derivatives","volume":"125","author":"Kempf","year":"1998","journal-title":"Development"},{"key":"S2040174409990043_ref9","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00050.2005"},{"key":"S2040174409990043_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8709.2005.00015.x"},{"key":"S2040174409990043_ref33","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4917fje"},{"key":"S2040174409990043_ref40","unstructured":"40. Anderson PA , Kleinman CS , Lister G , Talner NS . Cardiovascular function during normal fetal and neonatal development and with hypoxic stress. In Fetal and Neonatal Physiology (eds. Polin AR, Fox WW), 1998; pp. 876\u2013889. W.B. Saunders, Philadelphia."},{"key":"S2040174409990043_ref17","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.130708"},{"key":"S2040174409990043_ref29","first-page":"R1348","article-title":"Fetal responses to long-term hypoxemia in sheep","volume":"256","author":"Kitanaka","year":"1989","journal-title":"Am J Physiol"},{"key":"S2040174409990043_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(98)01010-1"},{"key":"S2040174409990043_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsgi.2005.04.011"},{"key":"S2040174409990043_ref30","first-page":"H399","article-title":"Right and left ventricular function in fetal sheep exposed to long-term high-altitude hypoxemia","volume":"262","author":"Kamitomo","year":"1992","journal-title":"Am J Physiol"},{"key":"S2040174409990043_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1957.02060040668009"},{"key":"S2040174409990043_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.1310020606"},{"key":"S2040174409990043_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66419-7"},{"key":"S2040174409990043_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.06.044"},{"key":"S2040174409990043_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8644(1998)107:27+<25::AID-AJPA3>3.0.CO;2-L"},{"key":"S2040174409990043_ref22","first-page":"H297","article-title":"A model for studying chronic reduction in uterine blood flow in pregnant sheep","volume":"242","author":"Clark","year":"1982","journal-title":"Am J Physiol"},{"key":"S2040174409990043_ref37","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000017497.47084.06"},{"key":"S2040174409990043_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsgi.2004.09.004"},{"key":"S2040174409990043_ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0708473"},{"key":"S2040174409990043_ref34","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn341"},{"key":"S2040174409990043_ref42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2005.tb00379.x"},{"key":"S2040174409990043_ref18","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.141572"},{"key":"S2040174409990043_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00217.x"},{"key":"S2040174409990043_ref44","first-page":"269","article-title":"Increased aortic intima-media thickness is related to lipid profile in newborns with intrauterine growth restriction","volume":"65","author":"Koklu","year":"2006","journal-title":"Horm Res"},{"key":"S2040174409990043_ref26","first-page":"R201","article-title":"Chronic fetal placental embolization and hypoxemia cause hypertension and myocardial hypertrophy in fetal sheep","volume":"272","author":"Murotsuki","year":"1997","journal-title":"Am J Physiol"},{"key":"S2040174409990043_ref6","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.079756"},{"key":"S2040174409990043_ref16","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200104000-00009"},{"key":"S2040174409990043_ref5","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00053.2003"},{"key":"S2040174409990043_ref14","first-page":"459","article-title":"Altitude, ethnic and sex differences in birthweight and length in Bolivia","volume":"52","author":"Haas","year":"1980","journal-title":"Hum Biol"}],"container-title":["Journal of Developmental Origins of Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2040174409990043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T17:55:51Z","timestamp":1633974951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2040174409990043\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S2040174409990043"],"URL":"https:\/\/doi.org\/10.1017\/s2040174409990043","relation":{},"ISSN":["2040-1744","2040-1752"],"issn-type":[{"value":"2040-1744","type":"print"},{"value":"2040-1752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,1]]}}}