{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:54:14Z","timestamp":1787500454337,"version":"build-2736575974"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T00:00:00Z","timestamp":1332201600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>\n                    We assessed vascular programming in genetically identical monochorionic twin pairs with twin-to-twin transfusion syndrome (TTTS) treated differently\n                    <jats:italic>in utero<\/jats:italic>\n                    by serial amnioreduction or fetal laser arterial photocoagulation. This case\u2013control study re-assessed four twin groups at median 11 years comprising 20 pairs of monochorionic diamniotic twins: nine treated by amnioreduction (TTTS-amnio) and eleven by laser (TTTS-laser) with seven monochorionic and six dichorionic control pairs. Outcome measures were current blood pressure (BP), brachio-radial arterial stiffness derived from pulse wave velocity (PWV), resting microcirculation (Flux) and response to heating and post-occlusive reactive hyperaemia measured using laser Doppler. Potential confounders [PWV and BP at first study, current height, weight, heart rate and twin type (ex-recipient, ex-donor or heavier\/lighter of pair)] were accounted for by Mixed Linear Models statistical methodology. PWV dichorionic &gt; monochorionic (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.024); systolic and diastolic BP dichorionic &gt; TTTS-amnio and TTTS-laser (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.004,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.02 and\n                    <jats:italic>P<\/jats:italic>\n                    = 0.005,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.02, respectively). Within-twin pair pattern of PWV discordance was similar in laser treated and dichorionic controls (heavier-born &gt; lighter), opposite to TTTS-amnio and monochorionic controls. Flux monochorionic &gt; dichorionic (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.044) and heavier &gt; lighter-born (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.024). TTTS-laser and dichorionic diamniotic showed greatest hyperaemic responses (dichorionic &gt; TTTS-amnio or monochorionic controls (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.007,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.025). Hyperaemic responses were slower in heavier-born twins (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.005). In summary, monochorionic twins had lower BP, arterial stiffness and increased resting vasodilatation than dichorionic twins implying shared fetal circulation affects vascular development. Vascular responses in laser-TTTS were similar to dichorionic and opposite to TTTS-amnio suggesting a lasting effect of fetal therapy on vascular health.\n                  <\/jats:p>","DOI":"10.1017\/s204017441200013x","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T08:46:42Z","timestamp":1332233202000},"page":"182-189","source":"Crossref","is-referenced-by-count":14,"title":["Vascular programming in twins: the effects of chorionicity and fetal therapy for twin-to-twin transfusion syndrome"],"prefix":"10.1017","volume":"3","author":[{"given":"H. M.","family":"Gardiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Barlas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Diemert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J. O.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Preece","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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