{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:01:35Z","timestamp":1754107295477},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T00:00:00Z","timestamp":1343088000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>The developmental origins hypothesis suggests that morbidity and premature mortality arise, in part, from adverse exposures <jats:italic>in utero<\/jats:italic> and early in development. Evidence suggests a connection between early nutritional deficits and adult morbidity; however, the effects on mortality have been less well studied and previous studies provide conflicting results. We extracted Finnish birth cohort death rates from the Human Mortality Database. Our test asks whether men or women born during the 1867\u20131868 Great Finnish Famine exhibited death rates in old age different from expected, based on death rates among Finnish cohorts born 1818\u20131866. We found no support for the argument that exposure to the Finnish famine <jats:italic>in utero<\/jats:italic> induced excess mortality from age 60 to 89 in either men or women. Our results suggest that the Finnish famine did not induce, via epigenetic changes or any other mechanism, premature mortality in older age among exposed individuals.<\/jats:p>","DOI":"10.1017\/s2040174412000517","type":"journal-article","created":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T07:17:19Z","timestamp":1343114239000},"page":"30-34","source":"Crossref","is-referenced-by-count":5,"title":["No evidence of programmed late-life mortality in the Finnish famine cohort"],"prefix":"10.1017","volume":"4","author":[{"given":"K.","family":"Saxton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Falconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Goldman-Mellor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Catalano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2012,7,24]]},"reference":[{"key":"S2040174412000517_ref22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-031210-101230"},{"key":"S2040174412000517_ref16","volume-title":"Time Series Analysis: Forecasting and Control","author":"Box","year":"1994"},{"key":"S2040174412000517_ref15","doi-asserted-by":"publisher","DOI":"10.2307\/1912791"},{"key":"S2040174412000517_ref20","doi-asserted-by":"publisher","DOI":"10.1017\/S0021932009003332"},{"key":"S2040174412000517_ref14","first-page":"165","volume-title":"Modern Mathematics for the Engineer","author":"Wiener","year":"1956"},{"key":"S2040174412000517_ref2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806560105"},{"key":"S2040174412000517_ref12","unstructured":"University of California, Berkeley (USA) and Max Planck Institute for Demographic Research (Germany). Human Mortality Database. Retrieved 1 June 2011, from www.mortality.org or www.humanmortality.de"},{"key":"S2040174412000517_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.02.059"},{"key":"S2040174412000517_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/BF01267899"},{"key":"S2040174412000517_ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2001.00336.x"},{"key":"S2040174412000517_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/65.2.297"},{"key":"S2040174412000517_ref19","volume-title":"Applied Time Series Analysis for the Social Sciences","author":"McCleary","year":"1980"},{"key":"S2040174412000517_ref10","unstructured":"Doblhammer G, van den Berg G, Lumey LH. Long-term effects of famine on life expectancy: a re-analysis of the Great Finnish Famine of 1866\u20131868. IZA Discussion Paper No. 5534. Available at: SSRN http:\/\/ssrn.com\/abstract=1771256"},{"key":"S2040174412000517_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym126"},{"key":"S2040174412000517_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-005-7921-0"},{"key":"S2040174412000517_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20590"},{"key":"S2040174412000517_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp353"},{"key":"S2040174412000517_ref25","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20590"},{"key":"S2040174412000517_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009067"},{"key":"S2040174412000517_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.6.1088"},{"key":"S2040174412000517_ref21","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyh007"},{"key":"S2040174412000517_ref9","volume-title":"Deprivation and Disease: Mortality During the Great Finnish Famine of the 1860s","author":"Pitk\u00e4nen","year":"1993"},{"key":"S2040174412000517_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq267"},{"key":"S2040174412000517_ref13","doi-asserted-by":"publisher","DOI":"10.1017\/S0021859600003750"},{"key":"S2040174412000517_ref18","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1988.10488367"}],"container-title":["Journal of Developmental Origins of Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2040174412000517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T19:45:23Z","timestamp":1556135123000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2040174412000517\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,24]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S2040174412000517"],"URL":"https:\/\/doi.org\/10.1017\/s2040174412000517","relation":{},"ISSN":["2040-1744","2040-1752"],"issn-type":[{"value":"2040-1744","type":"print"},{"value":"2040-1752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,24]]}}}