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By combining high altitude (HA) with the chick embryo model, we have previously isolated the direct effects of HA hypoxia on embryonic growth and cardiovascular development before hatching. This study isolated the effects of developmental hypoxia on cardiovascular function measured<jats:italic>in vivo<\/jats:italic>in conscious adult male and female chickens. Chick embryos were incubated, hatched and raised at sea level (SL, nine males and nine females) or incubated, hatched and raised at HA (seven males and seven females). At 6 months of age, vascular catheters were inserted under general anaesthesia. Five days later, basal blood gas status, basal cardiovascular function and cardiac baroreflex responses were investigated. HA chickens had significantly lower basal arterial PO<jats:sub>2<\/jats:sub>and haemoglobin saturation, and significantly higher haematocrit than SL chickens, independent of the sex of the animal. HA chickens had significantly lower arterial blood pressure than SL chickens, independent of the sex of the animal. Although the gain of the arterial baroreflex was decreased in HA relative to SL male chickens, it was increased in HA relative to SL female chickens. We show that development at HA lowers basal arterial blood pressure and alters baroreflex sensitivity in a sex-dependent manner at adulthood.<\/jats:p>","DOI":"10.1017\/s204017441200058x","type":"journal-article","created":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T08:25:11Z","timestamp":1348043111000},"page":"69-76","source":"Crossref","is-referenced-by-count":22,"title":["High altitude hypoxia and blood pressure dysregulation in adult chickens"],"prefix":"10.1017","volume":"4","author":[{"given":"E. A.","family":"Herrera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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