{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:23:04Z","timestamp":1770294184825,"version":"3.49.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T00:00:00Z","timestamp":1408665600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Investigators have suggested a link between birth weight and both hand and lumbar spine osteoarthritis (OA). In this study, we sought to extend these observations by investigating relationships between growth in early life, and clinical and radiological diagnoses of OA at the hand, knee and hip, among participants from the Hertfordshire Cohort Study. Data were available for 222 men and 222 women. Clinical OA was defined based on American College of Rheumatology criteria. Radiographs were taken of the knees and hips, and graded for the presence of osteophytes and overall Kellgren and Lawrence (KL) score. Lower weight at year one was associated with higher rates of clinical hand OA (OR 1.396, 95% CI 1.05, 1.85, <jats:italic>P<\/jats:italic>=0.021). Individuals with lower birth weights were more likely to have hip osteophytes (OR 1.512, 95% CI 1.14, 2.00, <jats:italic>P<\/jats:italic>=0.004) and this remained robust after adjustment for confounders. Furthermore, a low weight at one year was also associated with a higher osteophyte number in the lateral compartment of the knee, after adjustment for confounders (OR 1.388, 95% CI 1.01, 1.91, <jats:italic>P<\/jats:italic>=0.043). We have found further evidence of a relationship between early life factors and adult OA. These findings accord with previous studies.<\/jats:p>","DOI":"10.1017\/s2040174414000373","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T03:32:54Z","timestamp":1409023974000},"page":"453-458","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":30,"title":["Further evidence of the developmental origins of osteoarthritis: results from the Hertfordshire Cohort Study"],"prefix":"10.1017","volume":"5","author":[{"given":"M. A.","family":"Clynes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. H.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. A.","family":"Jameson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. C.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Aihie Sayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. M.","family":"Dennison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,8,22]]},"reference":[{"key":"S2040174414000373_ref29","first-page":"1032","article-title":"Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women: the Framingham Study","volume":"27","author":"Zhang","year":"2000","journal-title":"J Rheumatol"},{"key":"S2040174414000373_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23176"},{"key":"S2040174414000373_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(91)90026-V"},{"key":"S2040174414000373_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290816"},{"key":"S2040174414000373_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300811"},{"key":"S2040174414000373_ref13","first-page":"2473","article-title":"WOMAC: a 20-year experiential review of a patient-centered self-reported health status questionnaire","volume":"29","author":"Bellamy","year":"2002","journal-title":"J Rheumatol"},{"key":"S2040174414000373_ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-013-0531-0"},{"key":"S2040174414000373_ref26","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650100615"},{"key":"S2040174414000373_ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-14-138"},{"key":"S2040174414000373_ref18","doi-asserted-by":"publisher","DOI":"10.1136\/adc.71.4.288"},{"key":"S2040174414000373_ref27","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.1.17"},{"key":"S2040174414000373_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/art.10862"},{"key":"S2040174414000373_ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070085"},{"key":"S2040174414000373_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200007)43:7<1456::AID-ANR7>3.0.CO;2-M"},{"key":"S2040174414000373_ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta3230","article-title":"Economic evaluation of a primary care-based education programme for patients with osteoarthritis of the knee","volume":"3","author":"Lord","year":"1999","journal-title":"Health Technol Assess"},{"key":"S2040174414000373_ref5","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.11.958"},{"key":"S2040174414000373_ref17","doi-asserted-by":"publisher","DOI":"10.1136\/jech.50.1.47"},{"key":"S2040174414000373_ref20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119530"},{"key":"S2040174414000373_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi137"},{"key":"S2040174414000373_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90710-1"},{"key":"S2040174414000373_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.05.007"},{"key":"S2040174414000373_ref24","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380706"},{"key":"S2040174414000373_ref15","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"S2040174414000373_ref21","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390111"},{"key":"S2040174414000373_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/lds038"},{"key":"S2040174414000373_ref6","first-page":"678","article-title":"Birth weight, vitamin D receptor gene polymorphism, and risk of lumbar spine osteoarthritis","volume":"32","author":"Jordan","year":"2005","journal-title":"J Rheumatol"},{"key":"S2040174414000373_ref22","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.3.158"},{"key":"S2040174414000373_ref23","first-page":"1943","article-title":"Axial and hip bone mineral density and radiographic changes of osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging","volume":"23","author":"Lethbridge-Cejku","year":"1996","journal-title":"J Rheumatol"},{"key":"S2040174414000373_ref11","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0838"}],"container-title":["Journal of Developmental Origins of Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2040174414000373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T18:03:33Z","timestamp":1555869813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2040174414000373\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,22]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S2040174414000373"],"URL":"https:\/\/doi.org\/10.1017\/s2040174414000373","relation":{},"ISSN":["2040-1744","2040-1752"],"issn-type":[{"value":"2040-1744","type":"print"},{"value":"2040-1752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,22]]},"assertion":[{"value":"\u00a9 Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2014\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}