{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:56:43Z","timestamp":1783515403345,"version":"3.55.0"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T00:00:00Z","timestamp":1469404800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Prenatal and early-life environmental exposures play a key role in the development of atopy and allergic disease. The Family Atherosclerosis Monitoring In earLY life Study is a general, population-based Canadian birth cohort that prospectively evaluated prenatal and early-life traits and their association with atopy and\/or allergic disease. The study population included 901 babies, 857 mothers and 530 fathers. Prenatal and postnatal risk factors were evaluated through questionnaires collected during the antenatal period and at 1 year. The end points of atopy and allergic diseases in infants were evaluated through questionnaires and skin prick testing. Key outcomes included atopy (24.5%), food allergy (17.5%), cow\u2019s milk allergy (4.8%), wheezing (18.6%) and eczema (16%). The association between infant antibiotic exposure [odds ratio (OR): 2.04, 95% confidence interval (CI): 1.45\u20132.88] and increased atopy was noted in the multivariate analysis, whereas prenatal maternal exposure to dogs (OR: 0.60, 95% CI: 0.42\u20130.84) and acetaminophen (OR: 0.68, 95% CI: 0.51\u20130.92) was associated with decreased atopy. This population-based birth cohort in Canada demonstrated high rates of atopy, food allergy, wheezing and eczema. Several previously reported and some novel prenatal and postnatal exposures were associated with atopy and allergic diseases at 1 year of age.<\/jats:p>","DOI":"10.1017\/s2040174416000386","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T10:33:29Z","timestamp":1469442809000},"page":"665-671","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":18,"title":["Prenatal and early-life predictors of atopy and allergic disease in Canadian children: results of the Family Atherosclerosis Monitoring In earLY life (FAMILY) Study"],"prefix":"10.1017","volume":"7","author":[{"given":"T.","family":"Batool","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. L.","family":"Reece","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. K.","family":"Teo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Denburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Cyr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the FAMILY Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,7,25]]},"reference":[{"key":"S2040174416000386_ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055815"},{"key":"S2040174416000386_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/65.1.7"},{"key":"S2040174416000386_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02534.x"},{"key":"S2040174416000386_ref31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03850.x"},{"key":"S2040174416000386_ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02151.x"},{"key":"S2040174416000386_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.11.019"},{"key":"S2040174416000386_ref16","doi-asserted-by":"crossref","unstructured":"Tsakok T , McKeever TM , Yeo L , et al. Does early life exposure to antibiotics increase the risk of eczema? A systematic review. Br J Dermatol. 2013; 169, 983\u2013991.","DOI":"10.1111\/bjd.12476"},{"key":"S2040174416000386_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-012-0255-6"},{"key":"S2040174416000386_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.009"},{"key":"S2040174416000386_ref30","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt121"},{"key":"S2040174416000386_ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03610.x"},{"key":"S2040174416000386_ref21","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab2271"},{"key":"S2040174416000386_ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00296.x"},{"key":"S2040174416000386_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03018.x"},{"key":"S2040174416000386_ref25","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-48"},{"key":"S2040174416000386_ref27","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.11.958"},{"key":"S2040174416000386_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.11.014"},{"key":"S2040174416000386_ref20","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.947578"},{"key":"S2040174416000386_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2012.01.006"},{"key":"S2040174416000386_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03532.x"},{"key":"S2040174416000386_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.07.005"},{"key":"S2040174416000386_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(87)90292-2"},{"key":"S2040174416000386_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.06.029"},{"key":"S2040174416000386_ref18","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328349b166"},{"key":"S2040174416000386_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-09550-9_10"},{"key":"S2040174416000386_ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000334148"},{"key":"S2040174416000386_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2014.01.022"},{"key":"S2040174416000386_ref17","unstructured":"Russell SL , Gold MJ , Hartmaan M , et al. Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. 2012; 13, 440\u2013447."},{"key":"S2040174416000386_ref14","first-page":"195","article-title":"Determinants of the incidence of childhood asthma: a two-stage case-control study","volume":"169","author":"Marie-Jos\u00e9e","year":"2009","journal-title":"Am J Epidemiol"},{"key":"S2040174416000386_ref4","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.081745"},{"key":"S2040174416000386_ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-9-15"}],"container-title":["Journal of Developmental Origins of Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2040174416000386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T20:10:34Z","timestamp":1555618234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2040174416000386\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,25]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S2040174416000386"],"URL":"https:\/\/doi.org\/10.1017\/s2040174416000386","relation":{},"ISSN":["2040-1744","2040-1752"],"issn-type":[{"value":"2040-1744","type":"print"},{"value":"2040-1752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,25]]},"assertion":[{"value":"\u00a9 Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2016\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}