{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T07:04:06Z","timestamp":1649142246022},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Dilation and abnormal tortuosity of retinal vessels are the hallmarks of severe retinopathy of prematurity (ROP) in premature infants. The stages of ROP are defined by vessel appearance at the interface between the vascular and avascular retinal areas. Deregulated signaling pathways involving hypoxia-inducible factors such as vascular endothelial growth factor (VEGF) are involved in the pathogenesis of ROP. VEGF-antagonists are increasingly being used as \u2018off-label medication\u2019 to treat this condition, with some success. We present Baby SM (female), who was born prematurely at 24 weeks gestation in a tertiary neonatal intensive care unit, and with a birth weight of 640 g. On screening at 35 weeks postmenstrual age (PMA), she was noted to have ROP, which became severe by 37 weeks PMA. She received one dose of intravitreal VEGF antagonist (Bevacizumab), resulting in a decrease in vessel tortuosity and dilation. However, repeat imaging at 4 weeks showed a re-emergence of vessel tortuosity. We believe the observed changes demonstrate an inherent retinal microvascular plasticity in premature neonates. With improved survival of extremely premature neonates and the availability of retinal imaging technology, we are now able to observe this plasticity.<\/jats:p>","DOI":"10.1017\/s2040174416000817","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T08:23:09Z","timestamp":1485850989000},"page":"284-286","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Retinal microvascular plasticity in a premature neonate"],"prefix":"10.1017","volume":"8","author":[{"given":"Y.","family":"Kandasamy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Hartley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"S2040174416000817_ref2","doi-asserted-by":"publisher","DOI":"10.2306\/scienceasia1513-1874.2013.39.265"},{"key":"S2040174416000817_ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129383"},{"key":"S2040174416000817_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2008.09.012"},{"key":"S2040174416000817_ref3","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-1780"},{"key":"S2040174416000817_ref7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3218"},{"key":"S2040174416000817_ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007374"},{"key":"S2040174416000817_ref4","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1136\/bjo.2006.098582","article-title":"The early treatment for retinopathy of prematurity study: structural findings at age 2 years","volume":"90","author":"Good","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"S2040174416000817_ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000335123"},{"key":"S2040174416000817_ref6","doi-asserted-by":"crossref","unstructured":"Sankar MJ , Sankar J , Mehta M , Bhat V , Srinivasan R . Anti-vascular endothelial growth factor (VEGF) drugs for treatment of retinopathy of prematurity. Cochrane Database Syst Rev. 2016; (2), article no. CD009734.","DOI":"10.1002\/14651858.CD009734.pub2"},{"key":"S2040174416000817_ref9","doi-asserted-by":"crossref","unstructured":"Kandasamy Y , Hartley L , Rudd D , Smith R . The association between systemic vascular endothelial growth factor and retinopathy of prematurity in premature infants: a systematic review. Br J Ophthalmol. 2017; 101, 21\u201324.","DOI":"10.1136\/bjophthalmol-2016-308828"}],"container-title":["Journal of Developmental Origins of Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2040174416000817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T22:17:02Z","timestamp":1555539422000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2040174416000817\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,31]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S2040174416000817"],"URL":"https:\/\/doi.org\/10.1017\/s2040174416000817","relation":{},"ISSN":["2040-1744","2040-1752"],"issn-type":[{"value":"2040-1744","type":"print"},{"value":"2040-1752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,31]]},"assertion":[{"value":"\u00a9 Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2017\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}