{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:02:30Z","timestamp":1740157350940,"version":"3.37.3"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of moderate maternal nutrient reduction. Using 3 T MRI, we examined IUGR offspring (eight male, eight female; 5.7 years; human equivalent 25 years) and age-matched controls (eight male, eight female; 5.6 years) to quantify distal descending aortic cross-section (AC) and distensibility (AD). ANOVA showed decreased IUGR AC\/body surface area (0.9\u00b10.05 cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup><jats:italic>v<\/jats:italic>. 1.2\u00b10.06 cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup>, M\u00b1<jats:sc>s.e.m.<\/jats:sc>, <jats:italic>P<\/jats:italic>&lt;0.005) and AD (1.7\u00b10.2 <jats:italic>v<\/jats:italic>. 4.0\u00b10.5\u00d710<jats:sup>\u22123<\/jats:sup>\/mmHg, <jats:italic>P<\/jats:italic>&lt;0.005) without sex difference or group-sex interaction, suggesting intrinsic vascular pathology and impaired development persisting in adulthood. Future studies should evaluate potential consequences of these changes on coronary perfusion, afterload and blood pressure.<\/jats:p>","DOI":"10.1017\/s2040174417000770","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T02:00:31Z","timestamp":1507687231000},"page":"137-142","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Poor perinatal growth impairs baboon aortic windkessel function"],"prefix":"10.1017","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5517-7984","authenticated-orcid":false,"given":"A. H.","family":"Kuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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