{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:18:38Z","timestamp":1791872318688,"version":"4.3.4"},"reference-count":100,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The developmental origin of health and disease highlights the importance of the period of the first 1000 days (from the conception to the 2 years of life). The process of the gut microbiota establishment is included in this time window. Various perinatal determinants, such as cesarean section delivery, type of feeding, antibiotics treatment, gestational age or environment, can affect the pattern of bacterial colonization and result in dysbiosis. The alteration of the early bacterial gut pattern can persist over several months and may have long-lasting functional effects with an impact on disease risk later in life. As for example, early gut dysbiosis has been involved in allergic diseases and obesity occurrence. Besides, while it was thought that the fetus developed under sterile conditions, recent data suggested the presence of a microbiota\n                    <jats:italic>in utero<\/jats:italic>\n                    , particularly in the placenta. Even if the origin of this microbiota and its eventual transfer to the infant are nowadays unknown, this placental microbiota could trigger immune responses in the fetus and would program the infant\u2019s immune development during fetal life, earlier than previously considered. Moreover, several studies demonstrated a link between the composition of placental microbiota and some pathological conditions of the pregnancy. All these data show the evidence of relationships between the neonatal gut establishment and future health outcomes. Hence, the use of pre- and\/or probiotics to prevent or repair any early dysbiosis is increasingly attractive to avoid long-term health consequences.\n                  <\/jats:p>","DOI":"10.1017\/s2040174418000119","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T03:24:37Z","timestamp":1521689077000},"page":"590-597","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":154,"title":["The developing gut microbiota and its consequences for health"],"prefix":"10.1017","volume":"9","author":[{"given":"M.-J.","family":"Butel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.-J.","family":"Waligora-Dupriet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wydau-Dematteis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"key":"S2040174418000119_ref46","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-015-0038-1"},{"key":"S2040174418000119_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.08.017"},{"key":"S2040174418000119_ref40","doi-asserted-by":"publisher","DOI":"10.1038\/nri1394"},{"key":"S2040174418000119_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.09.021"},{"key":"S2040174418000119_ref31","doi-asserted-by":"publisher","DOI":"10.1186\/2049-2618-2-38"},{"key":"S2040174418000119_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2015.07.007"},{"key":"S2040174418000119_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.05.012"},{"key":"S2040174418000119_ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-016-0498-0"},{"key":"S2040174418000119_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.01.004"},{"key":"S2040174418000119_ref32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030594"},{"key":"S2040174418000119_ref8","first-page":"17","article-title":"The human neonatal gut microbiome: a brief review","volume":"3","author":"Gritz","year":"2015","journal-title":"Front Pediatr"},{"key":"S2040174418000119_ref17","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.121189"},{"key":"S2040174418000119_ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2015.01.013"},{"key":"S2040174418000119_ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.01.016"},{"key":"S2040174418000119_ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2016.09.001"},{"key":"S2040174418000119_ref38","doi-asserted-by":"publisher","DOI":"10.1186\/s40748-015-0007-4"},{"key":"S2040174418000119_ref49","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2014.952435"},{"key":"S2040174418000119_ref30","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-014-0325-0"},{"key":"S2040174418000119_ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2009.00553.x"},{"key":"S2040174418000119_ref7","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/20163201004"},{"key":"S2040174418000119_ref47","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12476"},{"key":"S2040174418000119_ref80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180167"},{"key":"S2040174418000119_ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050177"},{"key":"S2040174418000119_ref43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04139.x"},{"key":"S2040174418000119_ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.026"},{"key":"S2040174418000119_ref33","doi-asserted-by":"crossref","unstructured":"Roze JC , Ancel PY , Lepage P , et al. Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants. Am J Clin Nutr. 2017; 106, 821\u2013830.","DOI":"10.3945\/ajcn.117.152967"},{"key":"S2040174418000119_ref48","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12244"},{"key":"S2040174418000119_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.12238"},{"key":"S2040174418000119_ref41","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000243"},{"key":"S2040174418000119_ref20","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4272"},{"key":"S2040174418000119_ref99","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13042"},{"key":"S2040174418000119_ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08821"},{"key":"S2040174418000119_ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00094"},{"key":"S2040174418000119_ref77","doi-asserted-by":"publisher","DOI":"10.1038\/srep23129"},{"key":"S2040174418000119_ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.08.024"},{"key":"S2040174418000119_ref3","first-page":"100","volume-title":"Healthcare (Basel)","volume":"3","author":"Dietert","year":"2015"},{"key":"S2040174418000119_ref4","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.29810"},{"key":"S2040174418000119_ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158498"},{"key":"S2040174418000119_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2014.11.004"},{"key":"S2040174418000119_ref98","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-015-0055-2"},{"key":"S2040174418000119_ref50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02939.x"},{"key":"S2040174418000119_ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.02.021"},{"key":"S2040174418000119_ref91","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad2571"},{"key":"S2040174418000119_ref12","doi-asserted-by":"publisher","DOI":"10.1038\/nature11053"},{"key":"S2040174418000119_ref44","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad9378"},{"key":"S2040174418000119_ref90","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.07.008"},{"key":"S2040174418000119_ref37","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0850"},{"key":"S2040174418000119_ref28","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.11.5184-5188.2004"},{"key":"S2040174418000119_ref86","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00675"},{"key":"S2040174418000119_ref63","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-301141"},{"key":"S2040174418000119_ref84","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.01.193"},{"key":"S2040174418000119_ref35","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181d1b11e"},{"key":"S2040174418000119_ref97","first-page":"CD005496","article-title":"Probiotics for prevention of necrotizing enterocolitis in preterm infants","volume":"4","author":"Alfaleh","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"S2040174418000119_ref75","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2007.12.007"},{"key":"S2040174418000119_ref5","doi-asserted-by":"publisher","DOI":"10.1586\/eri.10.14"},{"key":"S2040174418000119_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuu016"},{"key":"S2040174418000119_ref54","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx021"},{"key":"S2040174418000119_ref34","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ468"},{"key":"S2040174418000119_ref78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.01.018"},{"key":"S2040174418000119_ref25","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00789-12"},{"key":"S2040174418000119_ref29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1409497111"},{"key":"S2040174418000119_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.09.041"},{"key":"S2040174418000119_ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.080"},{"key":"S2040174418000119_ref11","doi-asserted-by":"publisher","DOI":"10.1177\/0884533616670150"},{"key":"S2040174418000119_ref82","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.12.041"},{"key":"S2040174418000119_ref53","first-page":"pii: A5313","article-title":"Comparable risk of childhood asthma after vaginal delivery and emergency caesarean section","volume":"64","author":"Brix","year":"2017","journal-title":"Dan Med J"},{"key":"S2040174418000119_ref56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00961.x"},{"key":"S2040174418000119_ref58","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-11-68"},{"key":"S2040174418000119_ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2016.09.003"},{"key":"S2040174418000119_ref60","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12253"},{"key":"S2040174418000119_ref61","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab2271"},{"key":"S2040174418000119_ref62","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160349"},{"key":"S2040174418000119_ref64","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.27"},{"key":"S2040174418000119_ref65","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.42"},{"key":"S2040174418000119_ref66","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2014.119"},{"key":"S2040174418000119_ref67","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.05.052"},{"key":"S2040174418000119_ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2017.03.001"},{"key":"S2040174418000119_ref71","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2015.04.002"},{"key":"S2040174418000119_ref73","doi-asserted-by":"crossref","unstructured":"Yang Y , Tian J , Yang B . Targeting gut microbiome: a novel and potential therapy for autism. Life Sci. 2017; 194, 111\u2013119.","DOI":"10.1016\/j.lfs.2017.12.027"},{"key":"S2040174418000119_ref74","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2016.04.012"},{"key":"S2040174418000119_ref76","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008599"},{"key":"S2040174418000119_ref79","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01206-08"},{"key":"S2040174418000119_ref81","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000255663.47512.23"},{"key":"S2040174418000119_ref83","doi-asserted-by":"publisher","DOI":"10.1542\/neo.15-12-e537"},{"key":"S2040174418000119_ref85","doi-asserted-by":"publisher","DOI":"10.3390\/nu7085315"},{"key":"S2040174418000119_ref87","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0268-4"},{"key":"S2040174418000119_ref88","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1502875112"},{"key":"S2040174418000119_ref89","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01031"},{"key":"S2040174418000119_ref93","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.4.894"},{"key":"S2040174418000119_ref94","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert consensus document: the international scientific association for probiotics and prebiotics (isapp) consensus statement on the definition and scope of prebiotics","volume":"14","author":"Gibson","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"S2040174418000119_ref95","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.66"},{"key":"S2040174418000119_ref23","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.038893"},{"key":"S2040174418000119_ref96","doi-asserted-by":"publisher","DOI":"10.3920\/BM2015.0140"},{"key":"S2040174418000119_ref100","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2017.07.002"},{"key":"S2040174418000119_ref1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002533"},{"key":"S2040174418000119_ref14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002601107"},{"key":"S2040174418000119_ref68","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.240754"},{"key":"S2040174418000119_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2016.11.001"},{"key":"S2040174418000119_ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s40629-016-0118-0"},{"key":"S2040174418000119_ref92","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2014.165"}],"container-title":["Journal of Developmental Origins of Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2040174418000119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T03:32:06Z","timestamp":1570937526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2040174418000119\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,22]]},"references-count":100,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S2040174418000119"],"URL":"https:\/\/doi.org\/10.1017\/s2040174418000119","relation":{},"ISSN":["2040-1744","2040-1752"],"issn-type":[{"value":"2040-1744","type":"print"},{"value":"2040-1752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,22]]},"assertion":[{"value":"\u00a9 Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}