{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:06:04Z","timestamp":1777363564331,"version":"3.51.4"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"02","license":[{"start":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T00:00:00Z","timestamp":1537228800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Otitis media (OM) carries a tremendous global health burden and potentially severe long-term consequences. The objective of this study was to determine the impact of birth at different gestational ages on the incidence of childhood OM.<\/jats:p><jats:p>A population-based cohort analysis was conducted. All singleton deliveries occurring between 1991 and 2014 at a regional tertiary medical center were included. Gestational age on delivery was divided into six subgroups: early (&amp;lt;34 weeks gestation; 0 out of 7) and late (34 weeks gestation; 0 out of 7 to 36 weeks gestation; 6 out of 7) preterm, and early (37 weeks gestation; 0 out of 7 to 38 weeks gestation; 6 out of 7), full (39 weeks gestation; 0 out of 7 to 40 weeks gestation; 6 out of 7), late (41 weeks gestation; 0 out of 7 to 41 weeks gestation; 6 out of 7) and post (\u2a7e42 weeks 0 out of 7) term deliveries. Rates of OM-related hospitalizations up to 18 years of age were assessed. Weibull parametric hazards model was used to study the association between gestational age at birth and the risk for OM-related hospitalizations while controlling for potential confounders.<\/jats:p><jats:p>During the study period, 238,622 deliveries met the inclusion criteria. OM-related hospitalizations of the offspring (<jats:italic>n<\/jats:italic>=4724) were significantly more common in the preterm (early 3.6%, late 2.4%) and early-term born children (2.2%) and decreased gradually across the full (1.9%), late (1.7%) and post (1.6%) term groups (\u03c7<jats:sup>2<\/jats:sup>-test for trends<jats:italic>P<\/jats:italic>&amp;lt;0.001). In the Weibull regression model, early preterm, as well as early-term deliveries exhibited an independent association with pediatric OM (adjusted hazard ratios: 1.67 and 1.09, respectively,<jats:italic>P<\/jats:italic>&amp;lt;0.02).<\/jats:p><jats:p>Deliveries occurring at preterm and early term are associated with higher rates of pediatric OM-related hospitalizations, which decrease gradually as gestational age advances.<\/jats:p>","DOI":"10.1017\/s2040174418000685","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T08:14:25Z","timestamp":1537258465000},"page":"214-220","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["The association between gestational age and otitis media during childhood: a population-based cohort analysis"],"prefix":"10.1017","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7174-8591","authenticated-orcid":false,"given":"Majdi","family":"Imterat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Wainstock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Moran-Gilad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Sheiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asnat","family":"Walfisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2018,9,18]]},"reference":[{"key":"S2040174418000685_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.05.038"},{"key":"S2040174418000685_ref37","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.16176"},{"key":"S2040174418000685_ref30","doi-asserted-by":"publisher","DOI":"10.1086\/528685"},{"key":"S2040174418000685_ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0803267"},{"key":"S2040174418000685_ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00005237-200601000-00019"},{"key":"S2040174418000685_ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.6.728"},{"key":"S2040174418000685_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1987.tb10531.x"},{"key":"S2040174418000685_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-008-0836-8"},{"key":"S2040174418000685_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.6.1079"},{"key":"S2040174418000685_ref13","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2637"},{"key":"S2040174418000685_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.3.685"},{"key":"S2040174418000685_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13151"},{"key":"S2040174418000685_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1979.00790200023005"},{"key":"S2040174418000685_ref11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1542\/peds.62.2.198","volume":"62","year":"1978","journal-title":"Pediatrics"},{"key":"S2040174418000685_ref5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3488"},{"key":"S2040174418000685_ref10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1542\/peds.49.2.187","volume":"49","year":"1972","journal-title":"Pediatrics"},{"key":"S2040174418000685_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199812000-00002"},{"key":"S2040174418000685_ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.5.1451"},{"key":"S2040174418000685_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1651"},{"key":"S2040174418000685_ref1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111732"},{"key":"S2040174418000685_ref29","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318188d1c2"},{"key":"S2040174418000685_ref28","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq037"},{"key":"S2040174418000685_ref26","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.6235"},{"key":"S2040174418000685_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.07.015"},{"key":"S2040174418000685_ref24","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12342"},{"key":"S2040174418000685_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.02.005"},{"key":"S2040174418000685_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.08.068"},{"key":"S2040174418000685_ref21","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23529"},{"key":"S2040174418000685_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.04.042"},{"key":"S2040174418000685_ref31","first-page":"e20153555","year":"2016","journal-title":"Pediatrics"}],"container-title":["Journal 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