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Since both ovarian and reproductive functions depend on energy balance, the alterations in metabolism may be related to reproductive alterations. The present study aimed to evaluate the effect of androgen excess during prenatal life on ovarian fuel sensors and its consequences on steroidogenesis. To this end, pregnant rats were hyperandrogenized with testosterone and the following parameters were evaluated in their female offspring: follicular development, PPARG levels, adipokines (including leptin, adiponectin, and chemerin as ovarian fuel sensors), serum gonadotropins (LH and FSH), the mRNA of their ovarian receptors, and the expression of steroidogenic mediators. At 60 days of age, the prenatally hyperandrogenized (PH) female offspring displayed both an irregular ovulatory phenotype and an anovulatory phenotype with altered follicular development and the presence of cysts. Both PH groups showed altered levels of both proteins and mRNA of PPARG and a different expression pattern of the adipokines studied. Although serum gonadotropins were not impaired, there were alterations in the mRNA levels of their ovarian receptors. The steroidogenic mediators <jats:italic>Star<\/jats:italic>, <jats:italic>Cyp11a1<\/jats:italic>, <jats:italic>Cyp17a1<\/jats:italic>, and <jats:italic>Cyp19a1<\/jats:italic> were altered differently in each of the PH groups. We concluded that androgen excess during prenatal life leads to developmental programming effects that affect ovarian fuel sensors and steroidogenesis in a phenotype-specific way.<\/jats:p>","DOI":"10.1017\/s2040174419000126","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:13:57Z","timestamp":1558656837000},"page":"645-658","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Fetal programming by androgen excess in rats affects ovarian fuel sensors and steroidogenesis"],"prefix":"10.1017","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3498-7010","authenticated-orcid":false,"given":"Giselle Adriana","family":"Abruzzese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria 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