{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:47:33Z","timestamp":1779191253431,"version":"3.51.4"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although bariatric surgery is approved for a woman of child-bearing age with an interest in subsequent pregnancy, reports of<jats:italic>in utero<\/jats:italic>growth issues during pregnancy have garnered a closer look at the impact of maternal surgical weight loss on the pre- and postpartum periods. Offspring of dams having received vertical sleeve gastrectomy (VSG) are born small-for-gestational age and have increased risk for metabolic syndrome later in life. Here, we aimed to determine whether the postnatal catch-up growth trajectory of bariatric offspring may be affected by milk composition. Milk samples were collected at postnatal day 15\/16 from dams having received VSG surgery and fed a high-fat diet (HFD) (H-VSG), Sham surgery and fed chow (C-Sham), or Sham surgery and fed HFD (H-Sham). Milk obtained from H-VSG dams had elevated glucose (<jats:italic>P<\/jats:italic>&lt; 0.05) and significantly reduced triglyceride content (<jats:italic>P<\/jats:italic>&lt; 0.01). Milk from H-Sham dams had the lowest amount of milk protein (<jats:italic>P<\/jats:italic>&lt; 0.05). Fatty acid composition measured by fractionation was largely not affected by surgery but rather maternal diet. No difference was observed in milk leptin levels; however, insulin, adiponectin, and growth hormone levels were significantly increased in milk from H-VSG animals. H-Sham had the lowest level of immunoglobulin (Ig)A, whereas IgG was significantly reduced in H-VSG. Taken together, the quality of milk from H-VSG dams suggests that milk composition could be a factor in reducing the rate of growth during the lactation period.<\/jats:p>","DOI":"10.1017\/s2040174419000424","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T08:22:08Z","timestamp":1565338928000},"page":"71-77","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Nutrient and hormone composition of milk is altered in rodent dams post-bariatric surgery"],"prefix":"10.1017","volume":"11","author":[{"given":"Evangeline M.","family":"Deer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley","family":"Welch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy J.","family":"Seeley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1281-1682","authenticated-orcid":false,"given":"Bernadette E.","family":"Grayson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,8,9]]},"reference":[{"key":"S2040174419000424_ref36","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-015-0574-4"},{"key":"S2040174419000424_ref35","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181567ed4"},{"key":"S2040174419000424_ref33","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2008.0137"},{"key":"S2040174419000424_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2008.09.002"},{"key":"S2040174419000424_ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200225"},{"key":"S2040174419000424_ref21","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2018-0142"},{"key":"S2040174419000424_ref20","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/jn\/nxy085","article-title":"Bariatric surgery does not appear to affect women\u2019s breast-milk composition","volume":"148","author":"Ameye","year":"2018","journal-title":"J Nutr"},{"key":"S2040174419000424_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181ae32e3"},{"key":"S2040174419000424_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181e90b31"},{"key":"S2040174419000424_ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-017-0126-x"},{"key":"S2040174419000424_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(86)90153-8"},{"key":"S2040174419000424_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.07.007"},{"key":"S2040174419000424_ref19","unstructured":"19. 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