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Epigenetic transmission may also predispose descended generations to chronic diseases, such as obesity, type 2 diabetes, behavioral, and reproductive disorders. The present study sought to evaluate the influence of a high-fat-high-sugar (HFHS) diet supplied to Wistar rats from 25 to 90 days of life on reproductive and metabolic parameters in male generations F0, F1, and F2. The standard group received the normocaloric \u2013 Nuvilab Quimtia\u00ae \u20133.86 kcal\/kg. The hypercaloric diet (HD) group received the HFHS diet \u2013 PragSolu\u00e7\u00f5es\u00ae \u20134.77 kcal\/kg. Body weight, adiposity, F1 and F2 prepubertal age evaluations, oral glucose tolerance test, insulin tolerance test, organ weights, sperm count and morphology assessments, and histometric testicular analyses were performed. The HFHS diet promoted dyslipidemia, higher adiposity, lower relative organ weights, and higher mean kidney weight, decreased mean testicle and parenchyma weights and lower height of seminiferous epithelium (HE) for the F0 generation. F1 and F2 offspring of HD group displayed early preprepubertal development, although did not alter the metabolic parameters. Decreased HE and tubular testicular compartment volumetric density and increased intertubular testicular compartment volumetric density and volume in the F1 generation of HD group were observed. Alterations in histometry of intertubular testicular compartment were also noted. It is concluded that the HFHS experimental model altered only paternal metabolic parameters. However, reproductive parameters of the three generations were affected.<\/jats:p>","DOI":"10.1017\/s2040174419000904","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T09:54:23Z","timestamp":1579082063000},"page":"653-663","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":22,"title":["A paternal hypercaloric diet affects the metabolism and fertility of F1 and F2 Wistar rat generations"],"prefix":"10.1017","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7026-3752","authenticated-orcid":false,"given":"Leonardo Toshio","family":"Oshio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Eliza","family":"Andreazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2485-4268","authenticated-orcid":false,"given":"J\u00e9ssica 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