{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:46:12Z","timestamp":1774053972575,"version":"3.50.1"},"reference-count":50,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alterations in the maternal environment may impact on the fetal development. The objective of this study was to investigate the gastrointestinal consequences of maternal hypothyroidism for the male offspring from Wistar rats. The pregnant rats were divided into three groups: control (<jats:italic>C<\/jats:italic> \u2013 received water), experimental 1 [<jats:italic>E<\/jats:italic>1 \u2013 received methimazole (MMI) solution] during gestation and lactation, and experimental 2 (<jats:italic>E<\/jats:italic>2 \u2013 received MMI solution) during gestation. Maternal parameters evaluated: free <jats:italic>T<\/jats:italic>3 and <jats:italic>T<\/jats:italic>4, bodyweight variation, and water\/food intake. Offspring parameters evaluated: litter size, number of male\/female, free <jats:italic>T<\/jats:italic>3 and <jats:italic>T<\/jats:italic>4, stomach area, gastric ulcer susceptibility, small intestine length and weight, small intestine and distal colon motility, the stomach and intestinal weight\u2013body weight ratio (SW\/BW\u2013IW\/BW), and the accumulation of intestinal fluid. Maternal <jats:italic>T<\/jats:italic>3 and <jats:italic>T<\/jats:italic>4 from <jats:italic>E<\/jats:italic>1 were decreased when compared to the other groups. There were no differences for maternal water\/food intake and weight gain, litter size, and number of males and females. Regarding to offspring, free <jats:italic>T<\/jats:italic>3, SW\/BW, IW\/BW, and intestinal fluid accumulation were not different between the groups, but <jats:italic>T<\/jats:italic>4 was decreased in <jats:italic>E<\/jats:italic>1. However, 30-day-old pups from <jats:italic>E<\/jats:italic>1 and <jats:italic>E<\/jats:italic>2 were smaller with lower stomach and small intestine. Even more, <jats:italic>E<\/jats:italic>1 presented a lower ulcer index when compared to the <jats:italic>C<\/jats:italic>, while <jats:italic>E<\/jats:italic>2 had a higher distal colon transit. It can be concluded that maternal hypothyroidism impaired the total body development, as well as gastric and intestinal development, besides interfering with the susceptibility to the ulcer and intestinal transit of male offspring from Wistar rats.<\/jats:p>","DOI":"10.1017\/s204017442000029x","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T06:34:47Z","timestamp":1588142087000},"page":"286-292","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Effects of maternal hypothyroidism in the gastrointestinal system of male young offspring from Wistar rats"],"prefix":"10.1017","volume":"12","author":[{"given":"L\u00edvia Prometti","family":"de Rezende","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica","family":"Fortunato 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