{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:16:21Z","timestamp":1778573781753,"version":"3.51.4"},"reference-count":53,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study examined the link between two biological markers of stress vulnerability at 22\u201326 years of age and telomere length at 30\u201335 among extremely low birth weight (ELBW; &lt;1000 g) survivors and normal birth weight (NBW; &gt;2500 g) control participants. Sixteen ELBW and 22 NBW participants provided baseline afternoon salivary cortisol samples and resting frontal electroencephalogram (EEG) alpha asymmetry data at 22\u201326 years. Buccal cells were assayed for telomere length at 30\u201335 years. Analyses controlled for sex, postnatal steroid exposure, childhood socioeconomic status, time of cortisol sample collection, and body mass index at 22\u201326 years. Salivary cortisol and frontal asymmetry at age 22\u201326 independently predicted telomere length at age 30\u201335, such that relatively higher cortisol and greater relative right frontal asymmetry at rest predicted telomere shortening among NBW controls, but not among ELBW survivors. However, similar associations were not noted in ELBW survivors, suggesting that ELBW survivors may have different mechanisms of stress coping as a result of their early-life exposures. These findings offer preliminary evidence in support of the role of stress in the genesis of cellular senescence at least among those born at NBW, but that these links may differ in those born preterm.<\/jats:p>","DOI":"10.1017\/s2040174420000409","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T09:50:06Z","timestamp":1590745806000},"page":"328-334","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Extremely low birth weight influences the relationship between stress and telomere length in adulthood"],"prefix":"10.1017","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1419-7409","authenticated-orcid":false,"given":"Calan D.","family":"Savoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis A.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick O.","family":"McGowan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saroj","family":"Saigal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan J.","family":"Van Lieshout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"key":"S2040174420000409_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2014.02.002"},{"key":"S2040174420000409_ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00583.x"},{"key":"S2040174420000409_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2015.04.002"},{"key":"S2040174420000409_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2008.11.006"},{"key":"S2040174420000409_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12181"},{"key":"S2040174420000409_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2004.03.002"},{"key":"S2040174420000409_ref34","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0013-4694(58)90053-1","article-title":"Report of the committee on methods of clinical examination in electroencephalography","volume":"10","author":"Jasper","year":"1958","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"S2040174420000409_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12965"},{"key":"S2040174420000409_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2010.06.007"},{"key":"S2040174420000409_ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180082"},{"key":"S2040174420000409_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2007.12.004"},{"key":"S2040174420000409_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.06.025"},{"key":"S2040174420000409_ref46","doi-asserted-by":"publisher","DOI":"10.1002\/nur.21707"},{"key":"S2040174420000409_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199509000-00008"},{"key":"S2040174420000409_ref36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1992.tb02034.x"},{"key":"S2040174420000409_ref41","doi-asserted-by":"publisher","DOI":"10.1186\/1480-9222-13-3"},{"key":"S2040174420000409_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0511(96)05218-0"},{"key":"S2040174420000409_ref45","doi-asserted-by":"publisher","DOI":"10.1038\/srep31560"},{"key":"S2040174420000409_ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.12.004"},{"key":"S2040174420000409_ref14","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.53"},{"key":"S2040174420000409_ref35","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.55.11.1196"},{"key":"S2040174420000409_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.08.014"},{"key":"S2040174420000409_ref4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407162101"},{"key":"S2040174420000409_ref31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2009.01388.x"},{"key":"S2040174420000409_ref47","unstructured":"47. Hollingshead, AB. Two factor index of social position. Unpublished manuscript, Yale Univ."},{"key":"S2040174420000409_ref19","first-page":"1","article-title":"Cardiovascular responses to psychosocial stress reflect motivation state in adults born at extremely low birth weight","volume":"2","author":"Mathewson","year":"2015","journal-title":"Glob Pediatr Heal."},{"key":"S2040174420000409_ref53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170765"},{"key":"S2040174420000409_ref15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107759108"},{"key":"S2040174420000409_ref29","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12826"},{"key":"S2040174420000409_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02384-9"},{"key":"S2040174420000409_ref3","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201610111"},{"key":"S2040174420000409_ref48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322145111"},{"key":"S2040174420000409_ref37","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e318229acfc"},{"key":"S2040174420000409_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2018.01.009"},{"key":"S2040174420000409_ref52","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2015.00068"},{"key":"S2040174420000409_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05633-1"},{"key":"S2040174420000409_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.05.058"},{"key":"S2040174420000409_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2005.02.010"},{"key":"S2040174420000409_ref32","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3747"},{"key":"S2040174420000409_ref27","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2011.602146"},{"key":"S2040174420000409_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2014.04.005"},{"key":"S2040174420000409_ref43","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.2.381"},{"key":"S2040174420000409_ref21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01659.x"},{"key":"S2040174420000409_ref20","doi-asserted-by":"crossref","first-page":"208","DOI":"10.2174\/157339631003140722103523","article-title":"Early adversity and mental health: linking extremely low birth weight, emotion regulation, and internalizing disorders","volume":"10","author":"Waxman","year":"2014","journal-title":"Curr Pediatr Rev."},{"key":"S2040174420000409_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.02.010"},{"key":"S2040174420000409_ref23","article-title":"Mental health of extremely low birth weight survivors in their 30s","volume":"135","author":"Van Lieshout","journal-title":"Pediatrics"},{"key":"S2040174420000409_ref5","doi-asserted-by":"publisher","DOI":"10.1080\/10253890.2017.1328494"},{"key":"S2040174420000409_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.05.001"},{"key":"S2040174420000409_ref40","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100236"},{"key":"S2040174420000409_ref39","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V114.22.1083.1083"},{"key":"S2040174420000409_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-037504-2.50005-5"},{"key":"S2040174420000409_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.12.008"},{"key":"S2040174420000409_ref18","article-title":"Telomere length in preterm infants: a promising biomarker of early adversity and care in the Neonatal Intensive Care Unit?","volume":"8","author":"Provenzi","journal-title":"Front Endocrinol"}],"container-title":["Journal of Developmental Origins of Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2040174420000409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T10:07:12Z","timestamp":1616494032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2040174420000409\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,29]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S2040174420000409"],"URL":"https:\/\/doi.org\/10.1017\/s2040174420000409","relation":{},"ISSN":["2040-1744","2040-1752"],"issn-type":[{"value":"2040-1744","type":"print"},{"value":"2040-1752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,29]]},"assertion":[{"value":"\u00a9 Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2020","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}