{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:35:25Z","timestamp":1783539325204,"version":"3.55.0"},"reference-count":86,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Donor-conceived neonates have poorer birth outcomes, including low birth weight and preterm delivery that are associated with poorer long-term health in adulthood through the developmental origins of health and disease (DOHaD) theory. The aim of this study was to conduct the first investigation of the adult health outcomes of donor-conceived people. An online health survey was completed by 272 donor sperm-conceived adults and 877 spontaneously conceived adults from around the world. Donor and spontaneously conceived groups were matched for age, sex, height, smoking, alcohol consumption, exercise, own fertility and maternal smoking. Donor sperm-conceived adults had significantly higher reports of being diagnosed with type 1 diabetes (<jats:italic>P<\/jats:italic>= 0.031), thyroid disease (<jats:italic>P<\/jats:italic>= 0.031), acute bronchitis (<jats:italic>P<\/jats:italic>= 0.008), environmental allergies (<jats:italic>P<\/jats:italic>= 0.046), sleep apnoea (<jats:italic>P<\/jats:italic>= 0.037) and having ear tubes\/grommets surgically implanted (<jats:italic>P<\/jats:italic>= 0.046). This is the first study to investigate the health outcomes of adult donor sperm-conceived people. Donor sperm-conceived adults self-reported elevated frequencies of various health conditions. The outcomes are consistent with birth defect data from donor sperm treatment and are consistent with the DOHaD linking perturbed early growth and chronic disease in adulthood.<\/jats:p>","DOI":"10.1017\/s204017442000080x","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T14:40:40Z","timestamp":1598971240000},"page":"638-651","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Self-reported physical health status of donor sperm-conceived adults"],"prefix":"10.1017","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7281-9942","authenticated-orcid":false,"given":"Damian H.","family":"Adams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Gerace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl","family":"de Lacey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"S204017442000080X_ref17","doi-asserted-by":"publisher","DOI":"10.3390\/nu7031378"},{"key":"S204017442000080X_ref44","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1528577"},{"key":"S204017442000080X_ref9","volume-title":"The Fetal and Infant Origins of Adult Disease","author":"Barker","year":"1992"},{"key":"S204017442000080X_ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000487618"},{"key":"S204017442000080X_ref63","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70215-1"},{"key":"S204017442000080X_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.05.035"},{"key":"S204017442000080X_ref24","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174415007898"},{"key":"S204017442000080X_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-016-4250-3"},{"key":"S204017442000080X_ref25","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174418000272"},{"key":"S204017442000080X_ref11","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2018.23.1.4"},{"key":"S204017442000080X_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms018"},{"key":"S204017442000080X_ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2016.09.007"},{"key":"S204017442000080X_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-018-4712-x"},{"key":"S204017442000080X_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2011.01.001"},{"key":"S204017442000080X_ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.10.038"},{"key":"S204017442000080X_ref61","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181fb8e59"},{"key":"S204017442000080X_ref75","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu289"},{"key":"S204017442000080X_ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008095"},{"key":"S204017442000080X_ref86","doi-asserted-by":"publisher","DOI":"10.1111\/chso.12158"},{"key":"S204017442000080X_ref13","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt304"},{"key":"S204017442000080X_ref32","first-page":"63","volume-title":"The ART of Caring. Book of Abstracts","author":"Bourne","year":"2018"},{"key":"S204017442000080X_ref85","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey088"},{"key":"S204017442000080X_ref35","doi-asserted-by":"publisher","DOI":"10.1080\/03610920801893731"},{"key":"S204017442000080X_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-016-0637-6"},{"key":"S204017442000080X_ref83","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.02.033"},{"key":"S204017442000080X_ref27","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174416000489"},{"key":"S204017442000080X_ref57","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2003.69"},{"key":"S204017442000080X_ref47","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30685-X"},{"key":"S204017442000080X_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00014-4"},{"key":"S204017442000080X_ref67","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.538025"},{"key":"S204017442000080X_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01552-4"},{"key":"S204017442000080X_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2016.08.004"},{"key":"S204017442000080X_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2014.03.012"},{"key":"S204017442000080X_ref53","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-5526-3_5"},{"key":"S204017442000080X_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.06.001"},{"key":"S204017442000080X_ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2013.03.001"},{"key":"S204017442000080X_ref51","doi-asserted-by":"publisher","DOI":"10.2174\/1573396314666180813121652"},{"key":"S204017442000080X_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.10.038"},{"key":"S204017442000080X_ref56","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nux053"},{"key":"S204017442000080X_ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.04.053"},{"key":"S204017442000080X_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.1.33"},{"key":"S204017442000080X_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.03.012"},{"key":"S204017442000080X_ref70","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep214"},{"key":"S204017442000080X_ref59","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0701-9"},{"key":"S204017442000080X_ref71","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/854837"},{"key":"S204017442000080X_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms062"},{"key":"S204017442000080X_ref49","first-page":"390","article-title":"Infertility and assisted reproduction in Denmark. Epidemiology and psychosocial consequences","volume":"53","author":"Schmidt","year":"2006","journal-title":"Dan Med Bull."},{"key":"S204017442000080X_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.02.053"},{"key":"S204017442000080X_ref60","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.777422"},{"key":"S204017442000080X_ref84","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2017.11.008"},{"key":"S204017442000080X_ref45","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-015-0687-9"},{"key":"S204017442000080X_ref42","first-page":"13","article-title":"American Society for Reproductive Medicine. Assisted reproductive technology in the United States and Canada: 1993 results generated from the American Society for Reproductive Medicine\/Society for Assisted Reproductive Technology Registry","volume":"64","year":"1995","journal-title":"Fertil Steril."},{"key":"S204017442000080X_ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.06.060"},{"key":"S204017442000080X_ref72","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.37"},{"key":"S204017442000080X_ref54","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1193786"},{"key":"S204017442000080X_ref79","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep110"},{"key":"S204017442000080X_ref29","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew068"},{"key":"S204017442000080X_ref33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B."},{"key":"S204017442000080X_ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.12.021"},{"key":"S204017442000080X_ref52","doi-asserted-by":"publisher","DOI":"10.3928\/00904481-20151112-07"},{"key":"S204017442000080X_ref80","doi-asserted-by":"publisher","DOI":"10.1093\/jlb\/lsv045"},{"key":"S204017442000080X_ref74","doi-asserted-by":"publisher","DOI":"10.4161\/epi.28711"},{"key":"S204017442000080X_ref73","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2016.04.077"},{"key":"S204017442000080X_ref37","doi-asserted-by":"publisher","DOI":"10.1111\/and.12517"},{"key":"S204017442000080X_ref82","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der202"},{"key":"S204017442000080X_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00124-7"},{"key":"S204017442000080X_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms044"},{"key":"S204017442000080X_ref55","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3474-7"},{"key":"S204017442000080X_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.09.022"},{"key":"S204017442000080X_ref23","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13910"},{"key":"S204017442000080X_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.06.012"},{"key":"S204017442000080X_ref76","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2010.11.007"},{"key":"S204017442000080X_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)58621-X"},{"key":"S204017442000080X_ref78","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2010.01.001"},{"key":"S204017442000080X_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14257"},{"key":"S204017442000080X_ref65","first-page":"519","article-title":"The prognosis for children of mothers with preeclampsia. Part 2: long-term effects","volume":"109","author":"D\u00edaz Mart\u00ednez","year":"2011","journal-title":"Arch Argent Pediatr."},{"key":"S204017442000080X_ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080398"},{"key":"S204017442000080X_ref16","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare4030051"},{"key":"S204017442000080X_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18932"},{"key":"S204017442000080X_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.09.015"},{"key":"S204017442000080X_ref36","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13449"},{"key":"S204017442000080X_ref68","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.09.038"},{"key":"S204017442000080X_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.01.118"},{"key":"S204017442000080X_ref77","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.12.119"},{"key":"S204017442000080X_ref15","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174417000228"},{"key":"S204017442000080X_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01559-4"}],"container-title":["Journal of Developmental Origins of Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S204017442000080X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:07:16Z","timestamp":1723507636000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S204017442000080X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":86,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S204017442000080X"],"URL":"https:\/\/doi.org\/10.1017\/s204017442000080x","relation":{},"ISSN":["2040-1744","2040-1752"],"issn-type":[{"value":"2040-1744","type":"print"},{"value":"2040-1752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,28]]},"assertion":[{"value":"\u00a9 The Author(s), 2020. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}