{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:37:54Z","timestamp":1783593474255,"version":"3.55.0"},"reference-count":51,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alterations in the circadian cycle are known to cause physiological disorders in the hypothalamic\u2013pituitary\u2013adrenal and the hypothalamic\u2013pituitary\u2013gonadal axes in adult individuals. Therefore, the present study aimed to evaluate whether exposure of pregnant rats to constant light can alter the reproductive system development of male offspring. The dams were divided into two groups: a light\u2013dark group (LD), in which pregnant rats were exposed to an LD photoperiod (12\u00a0h\/12\u00a0h) and a light\u2013light (LL) group, in which pregnant rats were exposed to a photoperiod of constant light during the gestation period. After birth, offspring from both groups remained in the normal LD photoperiod (12\u00a0h\/12\u00a0h) until adulthood. One male of each litter was selected and, at adulthood (postnatal day (PND) 90), the trunk blood was collected to measure plasma testosterone levels, testes and epididymis for sperm count, oxidative stress and histopathological analyses, and the spermatozoa from the vas deferens to perform the morphological and motility analyses. Results showed that a photoperiod of constant light caused a decrease in testosterone levels, epididymal weight and sperm count in the epididymis, seminiferous tubule diameter, Sertoli cell number, and normal spermatozoa number. Histopathological damage was also observed in the testes, and stereological alterations, in the LL group. In conclusion, exposure to constant light during the gestational period impairs the reproductive system of male offspring in adulthood.<\/jats:p>","DOI":"10.1017\/s2040174420000975","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T06:03:22Z","timestamp":1603865002000},"page":"595-602","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Extended light period in the maternal circadian cycle impairs the reproductive system of the rat male offspring"],"prefix":"10.1017","volume":"12","author":[{"given":"Fernanda Mithie","family":"Ogo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaucia Eloisa Munhoz Lion","family":"Siervo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria Praxedes","family":"de Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia Gama de Barros","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suellen Ribeiro da Silva","family":"Scarton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Tereza Bittencourt","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Louren\u00e7o","family":"Cecchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a Name Colado","family":"Sim\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-4585","authenticated-orcid":false,"given":"Paulo Cezar de Freitas","family":"Mathias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-1131","authenticated-orcid":false,"given":"Glaura Scantamburlo Alves","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"S2040174420000975_ref14","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0540103"},{"key":"S2040174420000975_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(76)90563-4"},{"key":"S2040174420000975_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(01)00710-5"},{"key":"S2040174420000975_ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000184232"},{"key":"S2040174420000975_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt054"},{"key":"S2040174420000975_ref29","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2010007500083"},{"key":"S2040174420000975_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2009.03.007"},{"key":"S2040174420000975_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(01)00702-6"},{"key":"S2040174420000975_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(91)90073-W"},{"key":"S2040174420000975_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(79)81346-0"},{"key":"S2040174420000975_ref32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097713"},{"key":"S2040174420000975_ref49","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-0226"},{"key":"S2040174420000975_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.09.008"},{"key":"S2040174420000975_ref45","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt054"},{"key":"S2040174420000975_ref20","volume-title":"Stereological Methods: Volume I. 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