{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:50:46Z","timestamp":1773179446932,"version":"3.50.1"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis B and hepatitis C (HBV\/HCV) are important global public health concerns. We aimed to evaluate the association between maternal HBV\/HCV carrier status and long-term offspring neurological hospitalisations. A population-based cohort analysis compared the risk for long-term childhood neurological hospitalisations in offspring born to HBV\/HCV carrier vs. non-carrier mothers in a large tertiary medical centre between 1991 and 2014. Childhood neurological diseases, such as cerebral palsy, movement disorders or developmental disorders, were pre-defined based on ICD-9 codes as recorded in hospital medical files. Offspring with congenital malformations and multiple gestations were excluded from the study. A Kaplan\u2013Meier survival curve was constructed to compare cumulative neurological hospitalisations over time, and a Cox proportional hazards model was used to control for confounders. During the study period (1991\u20132014), 243,682 newborns met the inclusion criteria, and 777 (0.3%) newborns were born to HBV\/HCV mothers. The median follow-up was 10.51 years (0\u201318 years). The offspring from HBV\/HCV mothers had higher incidence of neurological hospitalisations (4.5 vs. 3.1%, hazard ratio (HR) = 1.91, 95% CI 1.37\u20132.67). Similarly, the cumulative incidence of neurological hospitalisations was higher in children born to HBV\/HCV carrier mothers (Kaplan\u2013Meier survival curve log-rank test <jats:italic>p<\/jats:italic> &lt; 0.001). The increased risk remained significant in a Cox proportional hazards model, which adjusted for gestational age, mode of delivery and pregnancy complications (adjusted HR = 1.40, 1.01\u20131.95, <jats:italic>p<\/jats:italic> = 0.049). We conclude that maternal HBV or HCV carrier status is an independent risk factor for the long-term neurological hospitalisation of offspring regardless of gestational age and other adverse perinatal outcomes.<\/jats:p>","DOI":"10.1017\/s2040174420001397","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T02:42:58Z","timestamp":1611196978000},"page":"115-119","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Maternal hepatitis B or C carrier status and long-term risk for offspring neurological morbidity: a population-based cohort 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