{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T18:25:35Z","timestamp":1751567135756,"version":"3.40.5"},"reference-count":85,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fructose (C<jats:sub>6<\/jats:sub>H<jats:sub>12<\/jats:sub>O<jats:sub>6<\/jats:sub>) is acutely obesogenic and is a risk factor for hypertension, cardiovascular disease, and nonalcoholic fatty liver disease. However, the possible long-lasting effects of early-life fructose consumption have not been studied. We tested for effects of early-life fructose and\/or wheel access (voluntary exercise) in a line of selectively bred High Runner (HR) mice and a non-selected Control (C) line. Exposures began at weaning and continued for 3 weeks to sexual maturity, followed by a 23-week \"washout\" period (equivalent to \u223c17 human years). Fructose increased total caloric intake, body mass, and body fat during juvenile exposure, but had no effect on juvenile wheel running and no important lasting effects on adult physical activity or body weight\/composition. Interestingly, adult maximal aerobic capacity (VO<jats:sub>2<\/jats:sub>max) was reduced in mice that had early-life fructose and wheel access. Consistent with previous studies, early-life exercise promoted adult wheel running. In a 3-way interaction, C mice that had early-life fructose and no wheel access gained body mass in response to 2 weeks of adult wheel access, while all other groups lost mass. Overall, we found some long-lasting positive effects of early-life exercise, but minimal effects of early-life fructose, regardless of the mouse line.<\/jats:p>","DOI":"10.1017\/s204017442200054x","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T05:33:30Z","timestamp":1664861610000},"page":"249-260","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Effects of early-life voluntary exercise and fructose on adult activity levels, body composition, aerobic capacity, and organ masses in mice bred for high voluntary wheel-running behavior"],"prefix":"10.1017","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8358-8003","authenticated-orcid":false,"given":"Marcell D.","family":"Cadney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-9022","authenticated-orcid":false,"given":"Ralph L.","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7411-3011","authenticated-orcid":false,"given":"Nicole E.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica P.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto A.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret P.","family":"Schmill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7062-7376","authenticated-orcid":false,"given":"David A.","family":"Hillis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7916-3552","authenticated-orcid":false,"suffix":"Jr.","given":"Theodore","family":"Garland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,10,4]]},"reference":[{"key":"S204017442200054X_ref8","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3945\/ajcn.112.057943","article-title":"Trends in sugar-sweetened beverage consumption among youth and adults in the United States: 1999-2010","volume":"98","author":"Kit","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"S204017442200054X_ref22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3945\/jn.116.238816","article-title":"Early-life sugar consumption affects the rat microbiome independently of 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\u201cprogress\u201d?","volume":"14","author":"Neel","year":"1962","journal-title":"Am J Hum Genet"},{"key":"S204017442200054X_ref7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3945\/an.112.003137","article-title":"Challenging the fructose hypothesis: new perspectives on fructose consumption and metabolism","volume":"4","author":"White","year":"2013","journal-title":"Adv Nutr"},{"key":"S204017442200054X_ref66","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.psc.2011.08.009","article-title":"Obesity and physical activity","volume":"34","author":"Jakicic","year":"2011","journal-title":"Psychiatr Clin North Am"},{"key":"S204017442200054X_ref36","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.beproc.2017.11.004","article-title":"High-runner mice have reduced incentive salience for a sweet-taste reward when housed with wheel access","volume":"146","author":"Thompson","year":"2018","journal-title":"Behav 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fructose diet exacerbates white adipose tissue thermogenic process in offspring upon exposure to cold temperature","volume":"120066","author":"Alzamendi","year":"2021","journal-title":"Life Sci"},{"key":"S204017442200054X_ref49","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.physbeh.2015.06.020","article-title":"Effects of early-onset voluntary exercise on adult physical activity and associated phenotypes in mice","volume":"149","author":"Acosta","year":"2015","journal-title":"Physiol Behav"},{"key":"S204017442200054X_ref31","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.physbeh.2016.02.003","article-title":"Diet-induced obesity resistance of adult female mice selectively bred for increased wheel-running behavior is reversed by single perinatal exposure to a high-energy diet","volume":"157","author":"Guidotti","year":"2016","journal-title":"Physiol 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