{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:15:13Z","timestamp":1776320113729,"version":"3.50.1"},"reference-count":73,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Compared to preterm appropriate for gestational age (AGA) fetuses, fetuses with fetal growth restriction (FGR) have earlier visualisation of coronary artery blood flow (CABF) but impaired cardiac function. This dichotomy remains uncharacterised during postnatal life. This study compared CABF and cardiac function in preterm FGR infants, against AGA infants during the postnatal period. FGR was defined as birthweight &lt; 10<jats:sup>th<\/jats:sup>centile for gestation and sex with absent\/reversed antenatal umbilical artery Doppler. Diastolic CABF was measured in the left anterior descending coronary artery. Twenty-eight FGR infants were compared with 26 AGA infants (gestation and birthweight, 29.7 \u00b1 1.3 vs 29.9 \u00b1 1 weeks,<jats:italic>P<\/jats:italic>= 0.6 and 918 \u00b1 174 vs 1398 \u00b1 263g,<jats:italic>P<\/jats:italic>&lt; 0.001, respectively). Echocardiography was performed in the second week of life. FGR infants had higher CABF (velocity time integral, 2.4 \u00b1 0.9 vs 1.6 \u00b1 0.8 cm,<jats:italic>P<\/jats:italic>= 0.002). Diastolic function was impaired (\u2191 trans-mitral E\/A ratio in FGR infants; 0.84 \u00b1 0.05 vs 0.79 \u00b1 0.03,<jats:italic>P<\/jats:italic>= 0.0002) while the systolic function was also affected (mean velocity of circumferential fibre shortening [mVCFc], 1.9 \u00b1 0.3 vs 2.7 \u00b1 0.5 circ\/s,<jats:italic>P<\/jats:italic>&lt; 0.001). Indexing CABF to cardiac function noted significant differences between the groups (CABF: E\/A [FGR vs AGA], 2.9 \u00b1 1.1 vs 2.1 \u00b1 1,<jats:italic>P<\/jats:italic>= 0.01 and CABF: mVCFc [FGR vs AGA], 1.3 \u00b1 0.5 vs 0.6 \u00b1 0.3,<jats:italic>P<\/jats:italic>&lt; 0.001). Diastolic blood pressure (BP) was significantly higher, and CABF to diastolic BP ratio trended higher in FGR infants (30 \u00b1 2 vs 25 \u00b1 3 mmHg,<jats:italic>P<\/jats:italic>&lt; 0.001 and 0.08 \u00b1 0.03 vs 0.06 \u00b1 0.03,<jats:italic>P<\/jats:italic>= 0.059, respectively). Greater CABF in FGR infants did not translate into better cardiac function. This dichotomy may be a persistent response to fetal hypoxaemia (fetal programming) and\/or reflection of altered cardiac architecture.<\/jats:p>","DOI":"10.1017\/s2040174422000630","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T09:37:00Z","timestamp":1669023420000},"page":"302-310","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["Myocardial perfusion and function dichotomy in growth restricted preterm infants"],"prefix":"10.1017","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2600-7529","authenticated-orcid":false,"given":"Arvind","family":"Sehgal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth J.","family":"Allison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme 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Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}