{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:46:36Z","timestamp":1786999596560,"version":"build-2736575974"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"unspecified","delay-in-days":56,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Dev Orig Health Dis"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Maternal hyperglycemia is associated with higher risk of metabolic diseases in offspring. Despite various hypotheses, the exact mechanisms remain unclear and the neural implication is yet to be fully investigated. The hypothalamus plays a critical role in energy regulation. In utero exposure to maternal hyperglycemia might selectively affect the developing hypothalamus. To test this hypothesis, we investigated associations between\n                    <jats:italic>in utero<\/jats:italic>\n                    exposure to maternal hyperglycemia and hypothalamic volume at 10\u201312 years of age. We included 82 mother\u2013child pairs from the Gen3G prospective birth cohort, followed up 10\u201312 years after birth. Women underwent a 75g Oral Glucose Tolerance Test (OGTT) at 24\u201330 weeks of gestation, and we calculated the area-under-the-curve of glucose (AUCgluc) from maternal glucose measurements at fasting, 1h and 2h during OGTT to reflect prenatal hyperglycemia exposure. During the follow-up visit at 10\u201312 years of age, a subsample of children (\n                    <jats:italic>n<\/jats:italic>\n                    = 82) completed 3 T brain magnetic resonance imaging (MRI) to quantify brain volumes with FreeSurfer 7. We used Pearson correlations and partial correlations with adjustments to test associations between the AUCgluc and offspring hypothalamic brain volumes. We found that higher maternal AUCgluc was associated with greater total offspring hypothalamic volume (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.30;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.006). In comparison, no other brain region was significantly correlated with the maternal AUCgluc. Correlations remain significant when adjusted for maternal or offspring\u2019s variables. Overall, we found that higher maternal glycemic response following OGTT in pregnancy appears associated with larger offspring hypothalamic volume. Our results suggest that prenatal exposure to hyperglycemia may lead to hypothalamic programming.\n                  <\/jats:p>","DOI":"10.1017\/s204017442510041x","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T07:56:53Z","timestamp":1772092613000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Maternal hyperglycemia during pregnancy is associated specifically with larger hypothalamic volumes at 12 years of age"],"prefix":"10.1017","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7651-0183","authenticated-orcid":false,"given":"C\u00e9drik","family":"Marchildon","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00kybxq39","id-type":"ROR","asserted-by":"publisher"}],"name":"Universit\u00e9 de Sherbrooke"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lina","family":"Arguin","sequence":"additional","affiliation":[{"name":"Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Doyon","sequence":"additional","affiliation":[{"name":"Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Sherbrooke"},{"name":"Bishop\u2019s University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9anne","family":"Michaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval"},{"name":"Institut Universitaire de Cardiologie et Pneumologie de Qu\u00e9bec - Universit\u00e9 Laval"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Huck","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00kybxq39","id-type":"ROR","asserted-by":"publisher"}],"name":"Universit\u00e9 de Sherbrooke"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Gingras","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al"},{"name":"Sainte-Justine University Hospital Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Perron","sequence":"additional","affiliation":[{"name":"Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7752-2585","authenticated-orcid":false,"given":"Marie-France","family":"Hivert","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Sherbrooke"},{"name":"Harvard Medical 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