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As puberty reflects the maturing of the reproductive system, this study investigated whether preconception exposure to low doses of malathion during juvenile and pubertal stages affects fertility and pregnancy outcomes in Wistar rats. Female rats received daily gavage doses of 10 or 50 mg\/kg from postnatal day (PND) 22 to 60. Puberty onset was monitored starting on PND 27. Following exposure, females were mated at the first proestrus and euthanized on gestational day (GD) 18. Malathion advanced puberty onset (M50) but did not impair fertility or serum hormonal levels. Females exposed to the higher dose showed increased urea levels. Additionally, placental integrity was compromised, with reduced placental glycogen (M10) and increased oxidative stress and reduced offspring CRL. These findings indicate that preconception exposure to low doses of malathion negatively impacted placentation and offspring\u2019s intrauterine development at GD 18.<\/jats:p>","DOI":"10.1017\/s2040174426100580","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:33:07Z","timestamp":1780914787000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Pre-conception exposure to low doses of malathion during the juvenile and pubertal periods impairs placentation and offspring fetal development in female\n                    <i>Wistar<\/i>\n                    rats"],"prefix":"10.1017","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0822-1679","authenticated-orcid":false,"given":"Giovanna Fachetti","family":"Frigoli","sequence":"first","affiliation":[{"name":"State University of Londrina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana Regina","family":"Costa","sequence":"additional","affiliation":[{"name":"State University of Londrina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Rodrigues","family":"Greghi","sequence":"additional","affiliation":[{"name":"State University of Londrina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Cremer","sequence":"additional","affiliation":[{"name":"State University of Londrina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Rocha","family":"Ten\u00f3rio","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabel Mello","family":"Martins","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Rodrigues Ferreira","family":"Seiva","sequence":"additional","affiliation":[{"name":"UNESP IBB"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0206-4986","authenticated-orcid":false,"given":"F\u00e1bio","family":"Goulart de Andrade","sequence":"additional","affiliation":[{"name":"State University of Londrina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phelipe Oliveira","family":"Favaron","sequence":"additional","affiliation":[{"name":"State University of Londrina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-1131","authenticated-orcid":false,"given":"Glaura Scantamburlo","family":"Fernandes","sequence":"additional","affiliation":[{"name":"State University of Londrina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"S2040174426100580_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32832924ba"},{"key":"S2040174426100580_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2015.01.010"},{"key":"S2040174426100580_ref21","doi-asserted-by":"publisher","DOI":"10.1590\/S1415-52732010000400013"},{"key":"S2040174426100580_ref68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.03.004"},{"key":"S2040174426100580_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(94)33041-7"},{"key":"S2040174426100580_ref72","doi-asserted-by":"publisher","DOI":"10.1210\/er.2011-1050"},{"key":"S2040174426100580_ref8","unstructured":"8. 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