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Recently, a study was carried out to describe depressive symptoms and the treatments provided under real-world circumstances to cardiac patients who entered the Mayo Clinic cardiac rehabilitation program. Antidepressant use was associated with reductions in depressive symptoms, but also with poorer cardiovascular outcomes. In this commentary, the results of this study are discussed in view of their clinical implications for everyday clinical practice and for the production of knowledge.<\/jats:p>","DOI":"10.1017\/s2045796018000380","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T12:21:32Z","timestamp":1532953292000},"page":"18-20","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Medicine-based evidence: the case of antidepressants in patients with coronary artery disease"],"prefix":"10.1017","volume":"28","author":[{"given":"C.","family":"Barbui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ostuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2018,7,30]]},"reference":[{"key":"S2045796018000380_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.07.002"},{"key":"S2045796018000380_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2005.00269.x"},{"key":"S2045796018000380_ref13","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796015000906"},{"key":"S2045796018000380_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S204579601300070X"},{"key":"S2045796018000380_ref10","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000019"},{"key":"S2045796018000380_ref9","first-page":"19","article-title":"AHA science advisory. 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