{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T06:24:27Z","timestamp":1789280667912,"version":"build-2803163510"},"reference-count":50,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"unspecified","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol Psychiatr Sci"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S2045796025100371_sec1a\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To synthesize the available experimental study evidence to estimate the effects of ketamine on suicide ideation (SI) in high-risk individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2045796025100371_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Double-blind randomized controlled trials and open-label studies investigating the safety and effectiveness of ketamine on SI published up to October 2025 were identified. Data were pooled using random-effects meta-analysis. The main outcome was standardized mean difference on SI in high-risk individuals. Secondary outcomes were the percentage of adverse events and the moderator effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2045796025100371_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 21 studies with a total of 927 participants meeting our inclusion criteria. The pooled effect size for the reduction of SI after ketamine treatment was significant and clinically meaningful (large effect size of\u00a0\u22121.40, 95% confidence interval:\u00a0\u22122.15 to\u00a0\u22120.66,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001, low\u2013quality evidence). Dissociation (38.8%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.014), nausea (31.6%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), dizziness (24.7%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.003), headache (22.0%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.011) and anxiety (15.8%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) were the frequently reported adverse events. Moderator analyses indicated that the effect was higher in younger individuals and those with severe SI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2045796025100371_sec4d\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings highlight the effectiveness of ketamine in reducing SI in high-risk individuals, especially younger individuals and those with severe ideation. Nonetheless, additional research is required to better understand optimal dosing regimens and the potential long-term effects of ketamine treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s2045796025100371","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:54:51Z","timestamp":1768208091000},"source":"Crossref","is-referenced-by-count":1,"title":["Ketamine treatment alleviates suicide ideation in high-risk populations: a systematic review and meta-analysis"],"prefix":"10.1017","volume":"35","author":[{"given":"Wen","family":"Tang","sequence":"first","affiliation":[{"name":"The Affiliated Taizhou People\u2019s Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Affiliated Taizhou People\u2019s Hospital of Nanjing Medical University"},{"name":"Nantong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Qian","family":"Que","sequence":"additional","affiliation":[{"name":"Affiliated Qidong Hospital of Nantong University"},{"name":"Qidong People\u2019s Hospital"},{"name":"Qidong Liver Cancer Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xuzhou Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8102-8994","authenticated-orcid":false,"given":"Hong-Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Nantong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Juan","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Affiliated Taizhou People\u2019s Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"S2045796025100371_ref36","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192113792"},{"key":"S2045796025100371_ref7","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.17060720"},{"key":"S2045796025100371_ref11","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13743"},{"key":"S2045796025100371_ref17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"S2045796025100371_ref34","doi-asserted-by":"publisher","DOI":"10.1002\/da.22253"},{"key":"S2045796025100371_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.09.037"},{"key":"S2045796025100371_ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01745-y"},{"key":"S2045796025100371_ref2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders 4th edition, text revision (DSM-IV-TR)","year":"2000"},{"key":"S2045796025100371_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.03.001"},{"key":"S2045796025100371_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.01.001"},{"key":"S2045796025100371_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.03.010"},{"key":"S2045796025100371_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.12.055"},{"key":"S2045796025100371_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12487"},{"key":"S2045796025100371_ref22","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.21m13921"},{"key":"S2045796025100371_ref31","doi-asserted-by":"publisher","DOI":"10.4103\/indianjpsychiatry.indianjpsychiatry_80_21"},{"key":"S2045796025100371_ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-021-03216-8"},{"key":"S2045796025100371_ref41","unstructured":"U.S. Food and Drug Administration (2019) FDA approves new nasal spray medication for treatment-resistant depression; available only at a certified doctor\u2019s office or clinic. 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