{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T08:06:53Z","timestamp":1784275613825,"version":"3.55.0"},"reference-count":65,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"unspecified","delay-in-days":197,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol Psychiatr Sci"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S2045796026100791_sec1a\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Unipolar mania (UM), defined by the occurrence of manic episodes without a history of depression, is a topic of debate within the classification of affective disorders. However, its epidemiological burden remains unclear. This systematic review and meta-analysis aimed to estimate the prevalence of UM among individuals with bipolar type I disorder (BD-I) while exploring potential sources of heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2045796026100791_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study protocol was registered in Open Science Framework on 27\u00a0March 2025. Embase, MEDLINE and APA PsycInfo were searched. We included observational studies reporting data on UM prevalence rates in adults with BD-I. Pooled prevalence was estimated using the Freeman\u2013Tukey double arcsine transformation, employing a restricted maximum likelihood random-effects model. Subgroup and meta-regression analyses were implemented to explore sources of heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2045796026100791_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 26 studies, encompassing 35 independent samples and 17,716 individuals with BD-I. The pooled prevalence of UM was 21.1% (95% confidence interval: 15.5\u201327.4%). Although potential publication bias was detected (Egger\u2019s\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.010), the trim-and-fill method did not impute any missing studies. No differences were found between clinical and community-based studies (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.966). However, prevalence estimates were influenced by both geographical area (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.020) and study quality (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014). Rate differences across studies may also be attributable\u00a0to variations in UM diagnostic definition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2045796026100791_sec4d\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>People with UM represent a significant subset of BD-I cases worldwide, warranting greater clinical awareness. The observed rate variability emphasizes the impact of sociocultural and methodological factors on UM diagnosis. Further research is necessary to refine diagnostic criteria and evaluate optimal treatment approaches for individuals with UM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s2045796026100791","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:46:00Z","timestamp":1784274360000},"source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of unipolar mania in bipolar I\u00a0disorder: a systematic review and meta-analysis of observational studies"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2612-4119","authenticated-orcid":false,"given":"Francesco","family":"Bartoli","sequence":"first","affiliation":[{"name":"University of Milano-Bicocca"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5342-9394","authenticated-orcid":false,"given":"Daniele","family":"Cavaleri","sequence":"additional","affiliation":[{"name":"University of 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