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To date, the models that have attempted to explain the relationship between traumatic, stressful events\u2019 meaning and clinical symptoms have been conducted in a piecemeal fashion. The objective of this study is to analyze which model (two-pathway model vs three-pathway model) has a better fit in explaining the association between the violation of global meaning and clinical symptoms such as somatization, anxiety, and depression in participants during the COVID-19 pandemic. The study sample consisted of\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a01106 adults. The results suggest that the violation of schemas affects depression and anxiety symptoms through three pathways: (a) Path one, directly, schema violation explains clinical symptoms; (b) Path two, indirectly, schema violation explains clinical symptoms through the search for meaning and negative effect; and (c) Path three, the presence of meaning explains positive affect and buffers clinical symptoms. The three-pathway model explains 90% of the variance in clinical symptoms. The three-pathway model has clinical implications for the assessment, prevention, and treatment of people who are coping with unforeseen negative situations.\n                  <\/jats:p>","DOI":"10.1017\/sjp.2026.10024","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:48:19Z","timestamp":1777366099000},"source":"Crossref","is-referenced-by-count":0,"title":["Relationship between Violation of Global Meaning and Clinical Symptoms during the COVID-19 Pandemic: A Three-Pathway Model"],"prefix":"10.1017","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-6452","authenticated-orcid":false,"given":"Jose-Heliodoro","family":"Marco-Salvador","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043nxc105","id-type":"ROR","asserted-by":"publisher"}],"name":"Universitat de 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