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Despite this exceptional correspondence, the two hemispheres also display important anatomical differences and there is marked lateralization of certain cognitive and motor functions such as language and handedness. However, the mechanisms that underlie the establishment of these hemispheric specializations, as well as their physiological and behavioral implications, remain largely unknown. Thanks to recent advances in neuroimaging, a series of studies documenting variation in symmetry and asymmetry as a function of age, gender, brain region, and pathological state, have been published in the past decade. Here, we review evidence of normal and atypical cerebral asymmetry, and the factors that influence it at the macrostructural level. Given the prominent role that cerebral asymmetry plays in the organization of the brain, and its possible implication in neurodevelopmental and psychiatric conditions, further research in this area is anticipated.<\/jats:p>","DOI":"10.1017\/thg.2012.13","type":"journal-article","created":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T12:58:16Z","timestamp":1339765096000},"page":"401-413","source":"Crossref","is-referenced-by-count":103,"title":["Cerebral Asymmetry: A Quantitative, Multifactorial, and Plastic Brain Phenotype"],"prefix":"10.1017","volume":"15","author":[{"given":"Miguel E.","family":"Renter\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2012,6,15]]},"reference":[{"key":"S1832427412000138_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410180210"},{"key":"S1832427412000138_ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1994.tb00622.x"},{"key":"S1832427412000138_ref84","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21055"},{"key":"S1832427412000138_ref72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801566105"},{"key":"S1832427412000138_ref77","doi-asserted-by":"publisher","DOI":"10.1177\/08830738020170122001"},{"key":"S1832427412000138_ref69","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.1004"},{"key":"S1832427412000138_ref64","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2626(84)90002-2"},{"key":"S1832427412000138_ref14","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0232"},{"key":"S1832427412000138_ref50","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl262"},{"key":"S1832427412000138_ref91","volume-title":"Der aphasische symptomencomplex. 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