{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:25:31Z","timestamp":1766136331894},"reference-count":56,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T00:00:00Z","timestamp":1339718400000},"content-version":"unspecified","delay-in-days":14,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Twin Res Hum Genet"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>The development of late-onset Alzheimer's disease (LOAD) is under strong genetic control and there is great interest in the genetic variants that confer increased risk. The Alzheimer's disease risk gene,<jats:italic>growth factor receptor bound protein 2-associated protein<\/jats:italic>(<jats:italic>GAB2<\/jats:italic>), has been shown to provide a 1.27\u20131.51 increased odds of developing LOAD for rs7101429 major allele carriers, in case-control analysis.<jats:italic>GAB2<\/jats:italic>is expressed across the brain throughout life, and its role in LOAD pathology is well understood. Recent studies have begun to examine the effect of genetic variation in the<jats:italic>GAB2<\/jats:italic>gene on differences in the brain. However, the effect of<jats:italic>GAB2<\/jats:italic>on the young adult brain has yet to be considered. Here we found a significant association between the<jats:italic>GAB2<\/jats:italic>gene and morphological brain differences in 755 young adult twins (469 females) (<jats:italic>M<\/jats:italic>= 23.1,<jats:italic>SD<\/jats:italic>= 3.1 years), using a gene-based test with principal components regression (PCReg). Detectable differences in brain morphology are therefore associated with variation in the<jats:italic>GAB2<\/jats:italic>gene, even in young adults, long before the typical age of onset of Alzheimer's disease.<\/jats:p>","DOI":"10.1017\/thg.2012.15","type":"journal-article","created":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T12:58:16Z","timestamp":1339765096000},"page":"286-295","source":"Crossref","is-referenced-by-count":13,"title":["Alzheimer's Disease Risk Gene,<i>GAB2<\/i>, is Associated with Regional Brain Volume Differences in 755 Young Healthy Twins"],"prefix":"10.1017","volume":"15","author":[{"given":"Derrek P.","family":"Hibar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Jahanshad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason 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