{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:05:17Z","timestamp":1762430717069},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T00:00:00Z","timestamp":1364860800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Twin Res Hum Genet"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p><jats:italic>Objective:<\/jats:italic>To evaluate the perinatal outcome of intrauterine growth-restricted preterm twins and contribution of prematurity to morbidity and mortality.<jats:italic>Study design:<\/jats:italic>A case\u2013control study of 211 preterm twins: 108 growth-restricted twins matched with 103 normal growth twins of the same gestational age. Mortality and morbidity rates were compared between groups.<jats:italic>Result:<\/jats:italic>Fetal and overall perinatal mortality rates of growth-restricted fetuses were higher than normal growth ones. Respiratory distress syndrome incidence was lower and neurologic sequelae incidence higher in growth-restricted twins. No differences were observed between groups with respect to neonatal mortality, low Apgar score, neonatal intensive care unit admission, periventricular hemorrhage, sepsis, jaundice, and hematologic or metabolic disorders.<jats:italic>Conclusion:<\/jats:italic>Adverse perinatal outcomes of preterm twins complicated with intrauterine growth restriction are represented by a higher antepartum mortality rate, but once born alive, neonatal outcomes seem to be associated only with gestational age at birth, excluding a protective effect on lung maturation and a higher risk of long-term neurologic sequelae.<\/jats:p>","DOI":"10.1017\/thg.2013.22","type":"journal-article","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T09:03:33Z","timestamp":1364893413000},"page":"727-731","source":"Crossref","is-referenced-by-count":8,"title":["Perinatal Outcomes in Preterm Growth-Restricted Twins: Effects of Gestational Age and Fetal Condition"],"prefix":"10.1017","volume":"16","author":[{"given":"Sebasti\u00e1n","family":"Manzanares","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Sanchez-Gila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda D.","family":"Moreno-Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Ramirez-Arredondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Pineda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,4,2]]},"reference":[{"key":"S1832427413000224_ref41","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000146634.28459.e8"},{"key":"S1832427413000224_ref13","first-page":"504","article-title":"Birth weight discordance, intrauterine growth retardation and perinatal outcomes in twins","volume":"39","author":"Fraser","year":"1994","journal-title":"Journal of Reproductive Medicine"},{"key":"S1832427413000224_ref17","first-page":"317","article-title":"Neonatal outcome of preterm discordant twins","volume":"39","author":"Haimovich","year":"2011","journal-title":"Journal of Perinatology Medicine"},{"key":"S1832427413000224_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(73)90404-3"},{"key":"S1832427413000224_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81204-1"},{"key":"S1832427413000224_ref30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904223401603"},{"key":"S1832427413000224_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(12)90849-2"},{"key":"S1832427413000224_ref37","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1542\/peds.95.4.534","article-title":"The small for gestational age infant: Accelerated or delayed pulmonary maturation? 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