{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T07:47:10Z","timestamp":1695023230184},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Twin Res Hum Genet"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>Non-syndromic agenesis of permanent teeth is one of the most common anomalies in human development, a multifactorial characteristic caused by genetic and environmental factors. We describe a pair of monozygotic twins who showed second premolar and third molar agenesis, albeit with different expressions. We studied the DNA of two genes, paired domain box gene 9 (<jats:italic>PAX9<\/jats:italic>) and muscle segment homeodomain-homeobox1 (<jats:italic>MSX1<\/jats:italic>), encoding transcription factors that earlier studies found were involved in the manifestation of this condition. No specific causative mutation was found. However, we detected a C\u2192T change in <jats:italic>MSX1<\/jats:italic> exon 2 in both twins, suggesting that this polymorphism might be involved in the trait's expression.<\/jats:p>","DOI":"10.1017\/thg.2013.69","type":"journal-article","created":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T09:17:24Z","timestamp":1381310244000},"page":"1112-1116","source":"Crossref","is-referenced-by-count":3,"title":["<i>MSX1<\/i> and <i>PAX9<\/i> Investigation in Monozygotic Twins With Variable Expression of Tooth Agenesis"],"prefix":"10.1017","volume":"16","author":[{"given":"Sofia I. N.","family":"Lopez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina S.","family":"Mundstock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa R.","family":"Paix\u00e3o-C\u00f4rtes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lav\u00ednia","family":"Sch\u00fcler-Faccini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Mundstock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C\u00e1tira","family":"Bortolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco M.","family":"Salzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,10,9]]},"reference":[{"key":"S1832427413000698_ref006","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015656"},{"key":"S1832427413000698_ref007","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509562103"},{"key":"S1832427413000698_ref003","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30212"},{"key":"S1832427413000698_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2010.10.020"},{"key":"S1832427413000698_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.02.012"},{"key":"S1832427413000698_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2012.78"},{"key":"S1832427413000698_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.09.005"},{"key":"S1832427413000698_ref010","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del133"},{"key":"S1832427413000698_ref004","doi-asserted-by":"publisher","DOI":"10.1038\/nature09534"},{"key":"S1832427413000698_ref008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2005.tb00347.x"}],"container-title":["Twin Research and Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1832427413000698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T02:24:47Z","timestamp":1555986287000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1832427413000698\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,9]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S1832427413000698"],"URL":"https:\/\/doi.org\/10.1017\/thg.2013.69","relation":{},"ISSN":["1832-4274","1839-2628"],"issn-type":[{"value":"1832-4274","type":"print"},{"value":"1839-2628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,9]]}}}