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Genome-wide association studies (GWAS) have been published for singleton-born individuals, but the role of genetic variation in birth weight (BW) in twins has not yet been fully investigated. A GWAS was performed in 4,593 female study participants with BW data available from the TwinsUK cohort. A genome-wide significant signal was found in chromosome 9, close to the <jats:italic>NTRK2<\/jats:italic> gene (OMIM: 600456). QIMR, an Australian twin cohort (<jats:italic>n<\/jats:italic> = 3,003), and UK-based singleton-birth individuals from the Hertfordshire cohort (<jats:italic>n<\/jats:italic> = 2,997) were used as replication for the top two single nucleotide polymorphism (SNPs) underpinning this signal, rs12340987 and rs7849941. The top SNP, rs12340987, was found to be in the same direction in the Australian twins and in the singleton-born females (fixed effects meta-analysis beta = -0.13, SE = 0.02, and <jats:italic>p<\/jats:italic> = 1.48 \u00d7 10<jats:sup>\u22128<\/jats:sup>) but not in the singleton-born males tested. These findings provide an important insight into the genetic component of BW in twins who are normally excluded due to their lower BW when compared with singleton births, as well as the difference in BW between twins. The <jats:italic>NTRK2<\/jats:italic> gene identified in this study has previously been associated with obesity.<\/jats:p>","DOI":"10.1017\/thg.2014.34","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T09:30:10Z","timestamp":1403256610000},"page":"254-261","source":"Crossref","is-referenced-by-count":14,"title":["Variants Close to <i>NTRK2<\/i> Gene Are Associated With Birth Weight in Female Twins"],"prefix":"10.1017","volume":"17","author":[{"given":"Sarah J.","family":"Metrustry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Medland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John 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