{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:00:38Z","timestamp":1759564838492},"reference-count":58,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Twin Res Hum Genet"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>Recent studies report a correlation between excision repair cross-complementing group 2 (ERCC2) Lys751Gln polymorphism and an increased risk of lung cancer, but results are controversial and inconclusive. Thus, we conducted a comprehensive meta-analysis in order to assess the correlation between them. Our study uses an odds ratio (OR) with a 95% confidence interval (95% CI) to evaluate the strength of the association; we also performed Begg's funnel plot and the Egger's test to assess the publication bias of previous articles. Finally, our meta-analysis is comprised of 28 full studies, including 23,370 subjects (10,242 cases and 13,128 controls). Our overall research shows that ERCC2 Lys751Gln polymorphism carries an increased risk of developing lung cancer (C vs. A: OR = 1.160, 95% CI = 1.081\u20131.245, <jats:italic>p<\/jats:italic> = .000; CC vs. AA: OR = 1.252, 95% CI = 1.130\u20131.388, <jats:italic>p<\/jats:italic> = .000; CA vs. AA: OR = 1.152, 95% CI = 1.060\u20131.252, <jats:italic>p<\/jats:italic> = .001; CC+CA vs. AA: OR = 1.186, 95% CI = 1.089\u20131.292, <jats:italic>p<\/jats:italic> = .000; CC vs. CA+AA: OR = 1.196, 95% CI = 1.087\u20131.316, <jats:italic>p<\/jats:italic> = .000). In ethnic subgroup analyses, we find a significant risk among Caucasians (C vs. A: OR = 1.106, 95% CI = 1.048\u20131.166, <jats:italic>p<\/jats:italic> = .000; CC vs. AA: OR = 1.233, 95% CI = 1.103\u20131.378, <jats:italic>p<\/jats:italic> = .000; CC+CA vs. AA: OR = 1.113, 95% CI = 1.033\u20131.199, <jats:italic>p<\/jats:italic> = .005; CC vs. CA+AA: OR = 1.185, 95% CI = 1.069\u20131.313, <jats:italic>p<\/jats:italic> = .001) and among Asians under two genetic models (CA vs. AA: OR = 1.265, 95% CI = 1.034\u20131.549, <jats:italic>p<\/jats:italic> = .023; CC+CA vs. AA: OR = 1.252, 95% CI = 1.015\u20131.544, <jats:italic>p<\/jats:italic> = .036). These results were confirmed by similar findings, demonstrated by stratified analyses in study design and histological typing. This meta-analysis indicates that ERCC2 Lys751Gln polymorphism may lead to an increased susceptibility to lung cancer risk among Caucasians and Asians.<\/jats:p>","DOI":"10.1017\/thg.2014.4","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T14:06:33Z","timestamp":1392905193000},"page":"99-107","source":"Crossref","is-referenced-by-count":10,"title":["Association Between ERCC2 Lys751Gln Polymorphism and Lung Cancer Risk: A Meta-Analysis Involving 23,370 Subjects"],"prefix":"10.1017","volume":"17","author":[{"given":"Xiang","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Xian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongyong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianji","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanbiao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingwu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,2,20]]},"reference":[{"key":"S1832427414000048_ref042","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.16.8658"},{"key":"S1832427414000048_ref032","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh264"},{"key":"S1832427414000048_ref026","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi280"},{"key":"S1832427414000048_ref048","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(02)00184-8"},{"key":"S1832427414000048_ref045","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-2507"},{"key":"S1832427414000048_ref027","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym234"},{"key":"S1832427414000048_ref013","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.8.1185"},{"key":"S1832427414000048_ref035","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2007.08.018"},{"key":"S1832427414000048_ref050","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-28-153"},{"key":"S1832427414000048_ref034","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.2.295"},{"key":"S1832427414000048_ref009","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-1005-x"},{"key":"S1832427414000048_ref021","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.4.59"},{"key":"S1832427414000048_ref030","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(01)00447-0"},{"key":"S1832427414000048_ref038","first-page":"1354","article-title":"Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients","volume":"61","author":"Spitz","year":"2001","journal-title":"Cancer Research"},{"key":"S1832427414000048_ref058","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi232"},{"key":"S1832427414000048_ref018","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2012.34"},{"key":"S1832427414000048_ref020","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31824de30f"},{"key":"S1832427414000048_ref019","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"S1832427414000048_ref011","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-0710-9"},{"key":"S1832427414000048_ref014","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"S1832427414000048_ref015","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.4.599"},{"key":"S1832427414000048_ref043","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn437"},{"key":"S1832427414000048_ref006","first-page":"911","article-title":"No association between the XPD (Lys751G1n) polymorphism or the XRCC3 (Thr241Met) polymorphism and lung cancer risk","volume":"10","author":"David-Beabes","year":"2001","journal-title":"Cancer Epidemiology, Biomarkers and Prevention"},{"key":"S1832427414000048_ref001","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/17.6.463"},{"key":"S1832427414000048_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-0657-7"},{"key":"S1832427414000048_ref037","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21117"},{"key":"S1832427414000048_ref033","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2010.11.018"},{"key":"S1832427414000048_ref036","first-page":"1","article-title":"Germ line variation in nucleotide excision repair genes and lung cancer risk in smokers","volume":"3","author":"Sakoda","year":"2012","journal-title":"International Journal of Molecular Epidemiology and Genetics"},{"key":"S1832427414000048_ref053","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181e7fe2a"},{"key":"S1832427414000048_ref044","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2003.11.001"},{"key":"S1832427414000048_ref047","first-page":"4103","article-title":"Reduced DNA repair capacity in lung cancer patients","volume":"56","author":"Wei","year":"1996","journal-title":"Cancer Research"},{"key":"S1832427414000048_ref057","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3892\/ol.2012.716","article-title":"Genetic polymorphisms of XPD and CDA and lung cancer risk","volume":"4","author":"Zhou","year":"2012","journal-title":"Oncology Letters"},{"key":"S1832427414000048_ref039","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-007-0328-4"},{"key":"S1832427414000048_ref028","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00638-9"},{"key":"S1832427414000048_ref012","doi-asserted-by":"publisher","DOI":"10.1002\/em.20031"},{"key":"S1832427414000048_ref049","first-page":"492","article-title":"Association of genetic polymorphism in the DNA repair gene XPD with risk of lung cancer in nonsmoking females","volume":"9","author":"Yin","year":"2006","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"S1832427414000048_ref004","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23801"},{"key":"S1832427414000048_ref003","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2012.00276"},{"key":"S1832427414000048_ref017","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0194"},{"key":"S1832427414000048_ref031","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.6.676"},{"key":"S1832427414000048_ref040","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"S1832427414000048_ref041","doi-asserted-by":"publisher","DOI":"10.1021\/bi00151a006"},{"key":"S1832427414000048_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2007.03.010"},{"key":"S1832427414000048_ref051","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2006.03.008"},{"key":"S1832427414000048_ref022","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-9-199711010-00008"},{"key":"S1832427414000048_ref005","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.8.1321"},{"key":"S1832427414000048_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2004.03.016"},{"key":"S1832427414000048_ref056","first-page":"1377","article-title":"Gene-environment interaction for the ERCC2 polymorphisms and cumulative cigarette smoking exposure in lung cancer","volume":"62","author":"Zhou","year":"2002","journal-title":"Cancer Research"},{"key":"S1832427414000048_ref008","first-page":"539","article-title":"Experimental studies in rat lungs on the carcinogenicity and dose-response relationships of eight frequently occurring environmental polycyclic aromatic hydrocarbons","volume":"71","author":"Deutsch-Wenzel","year":"1983","journal-title":"Journal of the National Cancer Institute"},{"key":"S1832427414000048_ref002","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi018"},{"key":"S1832427414000048_ref052","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22032"},{"key":"S1832427414000048_ref054","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-012-0625-7"},{"key":"S1832427414000048_ref025","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj189"},{"key":"S1832427414000048_ref023","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11136"},{"key":"S1832427414000048_ref055","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.05.008"},{"key":"S1832427414000048_ref046","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/j.1460-2075.1990.tb08260.x","article-title":"ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3","volume":"9","author":"Weber","year":"1990","journal-title":"EMBO Journal"},{"key":"S1832427414000048_ref029","first-page":"1181","article-title":"APEX1 Asp148Glu gene polymorphism is a risk factor for lung cancer in relation to smoking in Japanese","volume":"11","author":"Osawa","year":"2010","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"S1832427414000048_ref024","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-7-162"}],"container-title":["Twin Research and Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1832427414000048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T21:59:23Z","timestamp":1555970363000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1832427414000048\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,20]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S1832427414000048"],"URL":"https:\/\/doi.org\/10.1017\/thg.2014.4","relation":{},"ISSN":["1832-4274","1839-2628"],"issn-type":[{"value":"1832-4274","type":"print"},{"value":"1839-2628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,20]]}}}