{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:21:19Z","timestamp":1761513679488},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T00:00:00Z","timestamp":1439510400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Twin Res Hum Genet"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic>Hypospadias is associated with twinning. The incidence of hypospadias in monochorionic and dichorionic male twins is, however, yet to be determined.<jats:italic>Methods:<\/jats:italic>All medical records of monochorionic and dichorionic twins admitted to our neonatal nursery between January 2004 and August 2013 were reviewed for the presence of hypospadias.<jats:italic>Results:<\/jats:italic>A total of 350 monochorionic and 303 dichorionic male twins were included in the study. The incidence of hypospadias in monochorionic and dichorionic groups was 4% (14\/350) and 1% (3\/303) (<jats:italic>p<\/jats:italic>= .016) respectively. In 11 of the 15 twin couples, hypospadias occurred in the twin with the lowest birth weight. The rate of hypospadias in twin infants small-for-gestational-age group was 10% (6\/60) compared with 2% (11\/593) in the appropriate-for-gestational-age group (<jats:italic>p<\/jats:italic>= .002). In a multivariate analysis, both monochorionicity and small-for-gestational-age were independently associated with hypospadias, odds ratio 4.1 (95% confidence interval (CI): 1.1\u201314.7) and 6.1 (95% CI: 2.2\u201317.2) respectively.<jats:italic>Conclusions<\/jats:italic>: The incidence of hypospadias is four-fold higher in monochorionic twins compared with dichorionic twins. Hypospadias is also independently associated with small-for-gestational-age.<\/jats:p>","DOI":"10.1017\/thg.2015.55","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T06:09:26Z","timestamp":1439532566000},"page":"591-594","source":"Crossref","is-referenced-by-count":8,"title":["Higher Incidence of Hypospadias in Monochorionic Twins"],"prefix":"10.1017","volume":"18","author":[{"given":"Remco","family":"Visser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nienke C. M.","family":"Burger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik W.","family":"van Zwet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Hilhorst-Hofstee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique C.","family":"Haak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joop","family":"van den Hoek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick","family":"Oepkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,8,14]]},"reference":[{"key":"S1832427415000559_ref011","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr421"},{"key":"S1832427415000559_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65334-7"},{"key":"S1832427415000559_ref016","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.4.1112"},{"key":"S1832427415000559_ref007","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2001.00088.x"},{"key":"S1832427415000559_ref020","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2001.d01-109.x"},{"key":"S1832427415000559_ref017","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23156"},{"key":"S1832427415000559_ref013","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960122)61:3<216::AID-AJMG5>3.0.CO;2-S"},{"key":"S1832427415000559_ref010","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.3.473"},{"key":"S1832427415000559_ref002","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-006-0304-z"},{"key":"S1832427415000559_ref012","first-page":"209","article-title":"Intrauterine growth and intrauterine growth curves","volume":"37","author":"Kloosterman","year":"1969","journal-title":"Maandschrift Voor Kindergeneeskunde"},{"key":"S1832427415000559_ref001","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199907000-00005"},{"key":"S1832427415000559_ref014","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10084"},{"key":"S1832427415000559_ref019","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11745.x"},{"key":"S1832427415000559_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62294-8"},{"key":"S1832427415000559_ref021","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68992-6"},{"key":"S1832427415000559_ref018","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms002"},{"key":"S1832427415000559_ref004","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20247"},{"key":"S1832427415000559_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.09.058"},{"key":"S1832427415000559_ref008","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-35-18"},{"key":"S1832427415000559_ref022","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33140"},{"key":"S1832427415000559_ref003","doi-asserted-by":"crossref","unstructured":"Cameron A. H. (1968). The Birmingham twin survey. Proceedings of the Royal Society of Medicine, 61, 229\u2013234.","DOI":"10.1177\/003591576806100314"},{"key":"S1832427415000559_ref009","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den104"}],"container-title":["Twin Research and Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1832427415000559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T10:34:25Z","timestamp":1567074865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1832427415000559\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,14]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S1832427415000559"],"URL":"https:\/\/doi.org\/10.1017\/thg.2015.55","relation":{},"ISSN":["1832-4274","1839-2628"],"issn-type":[{"value":"1832-4274","type":"print"},{"value":"1839-2628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,14]]}}}