{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:21:53Z","timestamp":1777346513031,"version":"3.51.4"},"reference-count":63,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T00:00:00Z","timestamp":1445817600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Twin Res Hum Genet"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>Tic disorders are moderately heritable common psychiatric disorders that can be highly troubling, both in childhood and in adulthood. In this study, we report results obtained in the first epigenome-wide association study (EWAS) of tic disorders. The subjects are participants in surveys at the Netherlands Twin Register (NTR) and the NTR biobank project. Tic disorders were measured with a self-report version of the Yale Global Tic Severity Scale Abbreviated version (YGTSS-ABBR), included in the 8th wave NTR data collection (2008). DNA methylation data consisted of 411,169 autosomal methylation sites assessed by the Illumina Infinium HumanMethylation450 BeadChip Kit (HM450k array). Phenotype and DNA methylation data were available in 1,678 subjects (mean age = 41.5). No probes reached genome-wide significance (<jats:italic>p<\/jats:italic> &lt; 1.2 \u00d7 10<jats:sup>\u22127<\/jats:sup>). The strongest associated probe was cg15583738, located in an intergenic region on chromosome 8 (<jats:italic>p<\/jats:italic> = 1.98 \u00d7 10<jats:sup>\u22126<\/jats:sup>). Several of the top ranking probes (<jats:italic>p<\/jats:italic> &lt; 1 \u00d7 10<jats:sup>\u22124<\/jats:sup>) were in or nearby genes previously associated with neurological disorders (e.g., <jats:italic>GABBRI, BLM<\/jats:italic>, and <jats:italic>ADAM10<\/jats:italic>), warranting their further investigation in relation to tic disorders. The top significantly enriched gene ontology (GO) terms among higher ranking methylation sites included anatomical structure morphogenesis (GO:0009653, <jats:italic>p<\/jats:italic> = 4.6 \u00d7 10<jats:sup>\u221215<\/jats:sup>) developmental process (GO:0032502, <jats:italic>p<\/jats:italic> = 2.96 \u00d7 10<jats:sup>\u221212<\/jats:sup>), and cellular developmental process (GO:0048869, <jats:italic>p<\/jats:italic> = 1.96 \u00d7 10<jats:sup>\u221212<\/jats:sup>). Overall, these results provide a first insight into the epigenetic mechanisms of tic disorders. This first study assesses the role of DNA methylation in tic disorders, and it lays the foundations for future work aiming to unravel the biological mechanisms underlying the architecture of this disorder.<\/jats:p>","DOI":"10.1017\/thg.2015.72","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T06:18:44Z","timestamp":1445840324000},"page":"699-709","source":"Crossref","is-referenced-by-count":41,"title":["Epigenome-Wide Association Study of Tic Disorders"],"prefix":"10.1017","volume":"18","author":[{"given":"Nuno R.","family":"Zilh\u00e3o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanmukha S.","family":"Padmanabhuni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Pagliaroli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Barta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"BIOS Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk J. 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L.","family":"Baselmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"van Dongen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peristera","family":"Paschou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorret I.","family":"Boomsma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,10,26]]},"reference":[{"key":"S1832427415000729_ref058","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.09.002"},{"key":"S1832427415000729_ref063","unstructured":"Zilh\u00e3o N. R. , Olthof R. , Smit D. , Mathews C. M. , deLucchi K. , Cath D. C. , Boomsma D. I. , .\u00a0.\u00a0. Dolan C. V. (2015). Heritability of tic disorders: A twin-family study. 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