{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:20:20Z","timestamp":1792149620723,"version":"4.4.0"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T00:00:00Z","timestamp":1462233600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Twin Res Hum Genet"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p><jats:italic>Objective:<\/jats:italic> To investigate the occurrence of early-onset neonatal sepsis (EOS) in twin\u2013twin transfusion syndrome (TTTS) managed with laser surgery.<\/jats:p><jats:p><jats:italic>Study design:<\/jats:italic> We performed a prospective cohort study of all consecutive TTTS cases treated with laser surgery (TTTS group) delivered at the Leiden University Medical Center. We recorded the occurrence of EOS, defined as a positive blood culture \u226472 hours postpartum (proven sepsis) or administration of a full course of antibiotics due to risk factors or signs of sepsis, in the absence of a positive blood culture (suspected sepsis). Perinatal variables in the TTTS group were compared with uncomplicated monochorionic twins (no-TTTS group). A multivariate model was generated, examining the association between EOS and gestational age at birth, interval between laser surgery and birth, anterior placenta, laser period (first study period: 2002\u20132008; second study period: 2009\u20132015), and preterm premature rupture of membranes (PPROM).<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> The rates of combined suspected and proven EOS in the TTTS group and no-TTTS group were 16% (68\/416) and 10% (55\/542), respectively (relative ratio [RR] 1.74, 95% confidence interval [CI] 1.19\u20132.55). Multivariate analysis showed that EOS in the TTTS group was independently associated with lower gestational age at birth (odds ratio [OR] 0.75, 95% CI 0.63\u20130.88), first study period (OR 2.25, 95% CI 1.08\u20134.67) and PPROM (OR 2.47, 95% CI 1.28\u20134.75).<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic> The rate of EOS in the TTTS group is low, but increased compared to the no-TTTS group. EOS in TTTS is independently associated with premature delivery, earlier laser period, and PPROM.<\/jats:p>","DOI":"10.1017\/thg.2016.21","type":"journal-article","created":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T10:20:16Z","timestamp":1462270816000},"page":"234-240","source":"Crossref","is-referenced-by-count":5,"title":["Increased Risk Of Early-Onset Neonatal Sepsis After Laser Surgery For Twin-to-Twin Transfusion Syndrome"],"prefix":"10.1017","volume":"19","author":[{"given":"Liselotte E. 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(2012). Prevention of neonatal group-b streptococcal disease in the Netherlands [Preventie van neonatale groep-B streptokokkenziekte] version 2.0. 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