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Understanding the mechanisms through which genetic risk unfolds to influence these developmental outcomes is critical for developing prevention and intervention efforts, capturing key elements of Irv's research agenda and scientific legacy. In this study, we examined the role of parenting and personality in mediating the effect of genetic risk on adolescents\u2019 major depressive disorder and conduct disorder symptoms. Longitudinal data were drawn from a sample of 709 European American adolescents and their mothers from the Collaborative Studies on Genetics of Alcoholism. Results from multivariate path analysis indicated that adolescents\u2019 depressive symptoms genome-wide polygenic scores (DS_GPS) predicted lower parental knowledge, which in turn was associated with more subsequent major depressive disorder and conduct disorder symptoms. Adolescents\u2019 DS_GPS also had indirect effects on these outcomes via personality, with a mediating effect via agreeableness but not via other dimensions of personality. Findings revealed that the pattern of associations was similar across adolescent gender. Our findings emphasize the important role of evocative gene\u2013environment correlation processes and intermediate phenotypes in the pathways of risk from genetic predispositions to complex adolescent outcomes.<\/jats:p>","DOI":"10.1017\/thg.2018.36","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T06:50:24Z","timestamp":1532069424000},"page":"310-321","source":"Crossref","is-referenced-by-count":12,"title":["Understanding Mechanisms of Genetic Risk for Adolescent Internalizing and Externalizing Problems: The Mediating Role of Parenting and Personality"],"prefix":"10.1017","volume":"21","author":[{"given":"Jinni","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally I-Chun","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen K.","family":"Bucholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Edenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schuckit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle M.","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,7,20]]},"reference":[{"key":"S1832427418000361_ref072","doi-asserted-by":"publisher","DOI":"10.1007\/s10567-006-0011-3"},{"key":"S1832427418000361_ref070","doi-asserted-by":"publisher","DOI":"10.1037\/bul0000017"},{"key":"S1832427418000361_ref071","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000051"},{"key":"S1832427418000361_ref010","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1994.55.149"},{"key":"S1832427418000361_ref066","doi-asserted-by":"publisher","DOI":"10.1353\/mpq.2012.0008"},{"key":"S1832427418000361_ref023","doi-asserted-by":"publisher","DOI":"10.1017\/S0007125000161823"},{"key":"S1832427418000361_ref043","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579413000655"},{"key":"S1832427418000361_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2015.56"},{"key":"S1832427418000361_ref038","doi-asserted-by":"publisher","DOI":"10.1037\/a0034205"},{"key":"S1832427418000361_ref005","first-page":"228","article-title":"The collaborative study on the genetics of alcoholism","volume":"19","author":"Begleiter","year":"1995","journal-title":"Alcohol Research and Health"},{"key":"S1832427418000361_ref001","volume-title":"Diagnostic and statistical manual of mental disorders","year":"1994"},{"key":"S1832427418000361_ref044","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2017.78.442"},{"key":"S1832427418000361_ref027","doi-asserted-by":"publisher","DOI":"10.1080\/15374416.2014.958838"},{"key":"S1832427418000361_ref048","doi-asserted-by":"publisher","DOI":"10.1080\/15295192.2012.683357"},{"key":"S1832427418000361_ref004","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2495-7"},{"key":"S1832427418000361_ref025","doi-asserted-by":"publisher","DOI":"10.1016\/j.adolescence.2007.08.006"},{"key":"S1832427418000361_ref034","doi-asserted-by":"publisher","DOI":"10.1111\/1467-6494.00148"},{"key":"S1832427418000361_ref054","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3552"},{"key":"S1832427418000361_ref053","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291706007082"},{"key":"S1832427418000361_ref007","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-050817-084847"},{"key":"S1832427418000361_ref065","first-page":"424","article-title":"How do people make their own environment? 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