{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T14:33:20Z","timestamp":1648910000873},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Twin Res Hum Genet"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The epidemiology of heritable traits whose prevalence is determined by a balance between mutation and selection is often explored through deterministic models. Here, the properties are explored by simulation of a model population followed through a sequence of closely spaced time points. Mutation and birth and death occur randomly. The condition neurofibromatosis type 1 (NF1) is used as a point of reference. Critical parameters, such as mutation rates and selection forces, are not known precisely for NF1 so speculative values based on published data from Finland and other studies are proposed.<\/jats:p>","DOI":"10.1017\/thg.2019.47","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T10:09:18Z","timestamp":1564049358000},"page":"229-232","source":"Crossref","is-referenced-by-count":0,"title":["Variation in Prevalence of Rare Heritable Traits \u2014 A Simulation Study \u2014 Illustrated by Neurofibromatosis Type 1"],"prefix":"10.1017","volume":"22","author":[{"given":"Alan E.","family":"Stark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"S1832427419000471_ref2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.113"},{"key":"S1832427419000471_ref9","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.8.632"},{"key":"S1832427419000471_ref7","volume-title":"Outline of genetic epidemiology","author":"Morton","year":"1982"},{"key":"S1832427419000471_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.12.056"},{"key":"S1832427419000471_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33139"},{"key":"S1832427419000471_ref4","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.26.11.704"},{"key":"S1832427419000471_ref8","volume-title":"Physician to the gene pool: Genetic lessons and other stories","author":"Neel","year":"1994"},{"key":"S1832427419000471_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1988.tb00297.x"},{"key":"S1832427419000471_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.206532"},{"key":"S1832427419000471_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.6.1355"}],"container-title":["Twin Research and Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1832427419000471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T11:51:16Z","timestamp":1571313076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1832427419000471\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,25]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S1832427419000471"],"URL":"https:\/\/doi.org\/10.1017\/thg.2019.47","relation":{},"ISSN":["1832-4274","1839-2628"],"issn-type":[{"value":"1832-4274","type":"print"},{"value":"1839-2628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,25]]}}}