{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:10:57Z","timestamp":1772122257380,"version":"3.50.1"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"unspecified","delay-in-days":70,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Twin Res Hum Genet"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (\n                    <jats:italic>n<\/jats:italic>\n                    = 3261) completing the C-19 COVID-19 symptom tracker app allowed classical twin studies of COVID-19 symptoms, including predicted COVID-19, a symptom-based algorithm to predict true infection, derived from app users tested for SARS-CoV-2. We found heritability of 49% (32\u221264%) for delirium; 34% (20\u221247%) for diarrhea; 31% (8\u221252%) for fatigue; 19% (0\u221238%) for anosmia; 46% (31\u221260%) for skipped meals and 31% (11\u221248%) for predicted COVID-19. Heritability estimates were not affected by cohabiting or by social deprivation. The results suggest the importance of host genetics in the risk of clinical manifestations of COVID-19 and provide grounds for planning genome-wide association studies to establish specific genes involved in viral infectivity and the host immune response.\n                  <\/jats:p>","DOI":"10.1017\/thg.2020.85","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T05:08:03Z","timestamp":1612847283000},"page":"316-321","source":"Crossref","is-referenced-by-count":52,"title":["Self-Reported Symptoms of COVID-19, Including Symptoms Most Predictive of SARS-CoV-2 Infection, Are Heritable"],"prefix":"10.1017","volume":"23","author":[{"given":"Frances M. 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