{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:26:39Z","timestamp":1784834799156,"version":"3.55.0"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Twin Res Hum Genet"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Familial twinning and fertility traits were investigated in Nigerian mothers of dizygotic (DZ) twins (MoDZT; <jats:italic>N<\/jats:italic> = 972) and controls (<jats:italic>N<\/jats:italic> = 525) who responded to our person-to-person interview, which included questions on pregnancy history and family history of DZ twinning. Controls were defined as women who are not twins themselves and do not have twins in their first-degree relatives. Over 95% of the participants were Yoruba. We found that Nigerian MoDZT had an average of 4.0 (\u00b12.6) pairs of twins among their relatives, and of these, the prevalence of DZ twins was significantly higher than that of monozygotic (MZ) twins (45.9% vs. 25.8%). Controls had an average of 0.5 (\u00b10.4) pairs, and over 95% of the controls had no twins in their relatives. These results suggest genetic influences on DZ twinning in Nigerians. MoDZT were significantly younger in their mean age at first child, and had higher parity than controls, suggesting increased fertility in MoDZT. As compared to mothers with a single set of twins, mothers (<jats:italic>N<\/jats:italic> = 130) with multiple sets had significantly more twins among their relatives (5.4 pairs vs. 3.7 pairs) and had their first twins at a younger age (28.4 vs. 30.7 years), indicating that mothers with multiple sets of twins might have higher genetic propensity for twinning associated with earlier age at twin pregnancy. Our findings argue for genomewide association studies for DZ twinning in Nigerians, and may help to develop intervention strategies to overcome infertility\/subfertility problems.<\/jats:p>","DOI":"10.1017\/thg.2024.2","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T05:56:01Z","timestamp":1706680561000},"page":"12-17","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Family History of Twinning and Fertility Traits in Nigerian Mothers of Dizygotic Twins"],"prefix":"10.1017","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1635-7974","authenticated-orcid":false,"given":"Yoon-Mi","family":"Hur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4069-8020","authenticated-orcid":false,"given":"Nick","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olakunle","family":"Oginni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorret","family":"Boomsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki","family":"Hubers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdi","family":"Mbarek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"S1832427424000021_ref3","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0140-6736(03)14237-7","article-title":"Twinning","volume":"362,","author":"Hall","year":"2003","journal-title":"Lancet"},{"key":"S1832427424000021_ref11","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/304626a0","article-title":"Familial incidence of twinning","volume":"304,","author":"Parisi","year":"1983","journal-title":"Nature"},{"key":"S1832427424000021_ref13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/humrep\/dead131","article-title":"New insights into the (epi)genetics of twinning","volume":"39,","author":"van Dongen","year":"2023","journal-title":"Human Reproduction"},{"key":"S1832427424000021_ref7","first-page":"4","article-title":"Epidemiology of twin pregnancy","volume":"10,","author":"MacGillivray","year":"1988","journal-title":"Seminars in Perinetology"},{"key":"S1832427424000021_ref9","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/humrep\/dead247","article-title":"Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity","volume":"39,","author":"Mbarek","year":"2023","journal-title":"Human 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Genetics"},{"key":"S1832427424000021_ref4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/humupd\/dmm036","volume":"14,","author":"Hoekstra","year":"2008","journal-title":"Human Reproduction Update"},{"key":"S1832427424000021_ref8","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.ajhg.2016.03.008","article-title":"Identi\ufb01cation of common genetic variants in\ufb02uencing spontaneous dizygotic twinning and female fertility","volume":"98,","author":"Mbarek","year":"2016","journal-title":"The American Journal of Human Genetics"},{"key":"S1832427424000021_ref1","volume-title":"The biology of twinning in man","author":"Bulmer","year":"1970"},{"key":"S1832427424000021_ref10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1017\/S0001566000008746","article-title":"The twinning incidence of Nigeria","volume":"28,","author":"Nylander","year":"1979","journal-title":"Acta Geneticae Medicae et Gemellogie"},{"key":"S1832427424000021_ref6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/(SICI)1096-8628(19960122)61:3<237::AID-AJMG7>3.0.CO;2-R","article-title":"Genetic contribution to DZ twinning","volume":"61,","author":"Lewis","year":"1996","journal-title":"American Journal of Medical Genetics"}],"container-title":["Twin Research and Human 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Published by Cambridge University Press on behalf of International Society for Twin Studies","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}