{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:44:22Z","timestamp":1791884662182,"version":"4.3.4"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Twin Res Hum Genet"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Twin registries worldwide increasingly function as large-scale research infrastructures, enabling standardized phenotyping across the lifespan, integration of biological and environmental data streams, and international cross-cohort collaborative research and replications. This development is also taking place in Germany. The GERman Twin Registry Under Development (GERTRUD;\n                    <jats:uri xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.gertrud.info\">www.gertrud.info<\/jats:uri>\n                    ) was established in 2022 as the first nationwide research platform for recruiting twins and higher order multiples of all ages within Germany to support the large-scale genetically informative psychological, sociological, health, and neuroscience twin research at national and international levels. GERTRUD is being developed as a modular infrastructure that supports classical and extended twin family designs, combining annual core survey waves with optional embedded modules for intensive phenotyping (e.g., neuroimaging, smartphone-based assessments), biosampling, and linkage of participants\u2019 residential context to external geographic datasets via geospatial information systems (GIS). To operate within Germany\u2019s stringent data protection landscape, GERTRUD implements project-specific pseudonymisation, role-based access control, and contract-governed remote analysis access. This article describes GERTRUD\u2019s governance and legal\u2013technical framework, its multisource data architecture, and the potential for collaboration across Germany and internationally. Examples of early data implementations further illustrate that the continuously collected multimodal twin data constitute a critical asset, essential for successful harmonization, replication, and collaborative and integrative behavioral genetics research.\n                  <\/jats:p>","DOI":"10.1017\/thg.2026.10057","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:51:28Z","timestamp":1777877488000},"page":"258-268","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["The German Twin Registry (GERTRUD): Towards Harmonized, Multisource Twin Research"],"prefix":"10.1017","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0556-4616","authenticated-orcid":false,"given":"Moana","family":"Beyer","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02pp7px91","id-type":"ROR","asserted-by":"publisher"}],"name":"Max Planck Institute for Human Development"},{"id":[{"id":"https:\/\/ror.org\/01hcx6992","id-type":"ROR","asserted-by":"publisher"}],"name":"Humboldt-Universitat zu Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Kuznetsov","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02pp7px91","id-type":"ROR","asserted-by":"publisher"}],"name":"Max Planck Institute for Human Development"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"K\u00fchn","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02pp7px91","id-type":"ROR","asserted-by":"publisher"}],"name":"Max Planck Institute for Human Development"},{"name":"University Medical Center Hamburg-Eppendorf"},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin"},{"name":"Max Planck UCL Centre for Computational Psychiatry and Ageing Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"S1832427426100577_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(98)00017-8"},{"key":"S1832427426100577_ref21","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1055\/s-0043-125070","article-title":"Quo vadis Datenlinkage in Deutschland? 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Published by Cambridge University Press on behalf of International Society for Twin Studies","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}