{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:11:39Z","timestamp":1777558299034,"version":"3.51.4"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:00:00Z","timestamp":1234224000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"abstract":"<jats:p>The regular intake of tomatoes or its products has been associated with a reduced risk of chronic diseases and these effects have been mainly attributed to lycopene. Here, we evaluated the anti-inflammatory properties of lycopene and its protective effects on organ injury in two experimental models of inflammation. In order to study the effects of lycopene in local inflammation, a carrageenan-induced paw oedema model in rats was performed. Lycopene was administered as an acute (1, 10, 25 or 50\u00a0mg\/kg, intraperitoneally, 15\u00a0min before carrageenan injection) and chronic treatment (25 or 50\u00a0mg\/kg per d, 14\u00a0d). Inflammation was assessed by the measurement of paw volume increase after 6\u00a0h. Lycopene significantly inhibited paw oedema formation at two doses (25 and 50\u00a0mg\/kg) in both acute and repeated administration. The effect of lycopene on liver inflammation was evaluated in a liver ischaemia\u2013reperfusion (I\/R) model. Rats were subjected to 45\u00a0min of ischaemia of three-quarters of the liver followed by 2\u00a0h of reperfusion. In this model, lycopene was administered daily at two doses (25 and 50\u00a0mg\/kg) during the 14\u00a0d that preceded the experiments. Repeated administration of lycopene reduced liver injury induced by I\/R, as demonstrated by the reduction of the increase in liver injury markers (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase and \u03b3-glutamyl transferase) and attenuation of liver tissue lipoperoxidation was evidenced by a decrease in malondialdehyde production. The present results show that lycopene exhibited local anti-inflammatory activity and also attenuated liver injury induced by I\/R. We speculate that lycopene administration might be useful in the pharmacological modulation of inflammatory events.<\/jats:p>","DOI":"10.1017\/s0007114508137886","type":"journal-article","created":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T11:15:01Z","timestamp":1234264501000},"page":"126-133","source":"Crossref","is-referenced-by-count":78,"title":["Anti-inflammatory effect of lycopene on carrageenan-induced paw oedema and hepatic ischaemia\u2013reperfusion in the rat"],"prefix":"10.1017","volume":"102","author":[{"given":"Let\u00edcia","family":"Bignotto","sequence":"first","affiliation":[]},{"given":"Jo\u00e3o","family":"Rocha","sequence":"additional","affiliation":[]},{"given":"Bruno","family":"Sepodes","sequence":"additional","affiliation":[]},{"given":"Maria","family":"Eduardo-Figueira","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Marco","family":"Chaud","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"de Carvalho","sequence":"additional","affiliation":[]},{"suffix":"Jr","given":"Heitor","family":"Moreno","sequence":"additional","affiliation":[]},{"given":"Helder","family":"Mota-Filipe","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2009,2,10]]},"reference":[{"key":"S0007114508137886_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(97)00280-3"},{"key":"S0007114508137886_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.23.1767"},{"key":"S0007114508137886_ref22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0031-6997(24)01484-4","article-title":"Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia\/reperfusion injury","volume":"53","author":"Cuzzocrea","year":"2001","journal-title":"Pharmacol Rev"},{"key":"S0007114508137886_ref27","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20504"},{"key":"S0007114508137886_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.12.012"},{"key":"S0007114508137886_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199711270-00004"},{"key":"S0007114508137886_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00573-0"},{"key":"S0007114508137886_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.05.017"},{"key":"S0007114508137886_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230315"},{"key":"S0007114508137886_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.08.007"},{"key":"S0007114508137886_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711040103"},{"key":"S0007114508137886_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500020609"},{"key":"S0007114508137886_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(89)90467-0"},{"key":"S0007114508137886_ref14","first-page":"77","article-title":"Effects of anti-inflammatory drugs on the carrageenin-induced hind paw inflammation of rats deprived of endogenous precursors of prostaglandins","volume":"2","author":"Bonta","year":"1977","journal-title":"Agents Actions Suppl"},{"key":"S0007114508137886_ref5","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.63.78"},{"key":"S0007114508137886_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.5.1226"},{"key":"S0007114508137886_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.03.050"},{"key":"S0007114508137886_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/62.6.1315S"},{"key":"S0007114508137886_ref10","doi-asserted-by":"publisher","DOI":"10.1177\/153537020222701013"},{"key":"S0007114508137886_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.8.2030S"},{"key":"S0007114508137886_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1998.tb01691.x"},{"key":"S0007114508137886_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2005.02.017"},{"key":"S0007114508137886_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1336-z"},{"key":"S0007114508137886_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-006-9141-7"},{"key":"S0007114508137886_ref21","doi-asserted-by":"publisher","DOI":"10.1021\/jf010586o"},{"key":"S0007114508137886_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.6.1691S"},{"key":"S0007114508137886_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S0273-2300(03)00004-7"},{"key":"S0007114508137886_ref16","first-page":"BR444","article-title":"The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat","volume":"8","author":"Mota-Filipe","year":"2002","journal-title":"Med Sci Monit"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114508137886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:26:00Z","timestamp":1738941960000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114508137886\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,10]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7,14]]}},"alternative-id":["S0007114508137886"],"URL":"https:\/\/doi.org\/10.1017\/s0007114508137886","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,10]]}}}