{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:31:07Z","timestamp":1778599867723,"version":"3.51.4"},"reference-count":64,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T00:00:00Z","timestamp":1424908800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2015,3,14]]},"abstract":"<jats:p>Diabetes mellitus (DM) is a major public health problem and its incidence is rising dramatically. The brain, particularly the cerebral cortex, is very susceptible to glucose fluctuations and hyperglycaemia-induced oxidative stress. Tea (<jats:italic>Camellia sinensis<\/jats:italic> (L.)) is widely consumed; however, the antidiabetic properties of white tea remain largely unexplored. In the present study, we investigated the effects of daily consumption of white tea on the cerebral cortex of prediabetic rats. The cerebral cortex metabolic profile was evaluated, and the expression levels of GLUT, phosphofructokinase-1, lactate dehydrogenase (LDH) and monocarboxylate transporter 4 were assessed. LDH activity was also determined. The cerebral cortex oxidative profile was determined by evaluating its antioxidant power, lipid peroxidation and protein oxidation levels. Catalase, glutathione, glutamate, <jats:italic>N<\/jats:italic>-acetylaspartate, aspartate, choline, \u03b3-aminobutyric acid, taurine and valine contents were determined. Daily consumption of white tea ameliorated glucose tolerance and insulin sensitivity. Moreover, white tea altered the cortex glycolytic profile, modulating GLUT expression and lactate and alanine contents. Finally, white tea consumption restored protein oxidation and lipid peroxidation levels and catalase expression, and improved antioxidant capacity. In conclusion, daily consumption of white tea improved the cerebral cortex metabolic and oxidative profile in prediabetic rats, suggesting it as a good, safe and inexpensive strategy to prevent DM-related effects in the cerebral cortex.<\/jats:p>","DOI":"10.1017\/s0007114514004395","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T10:37:12Z","timestamp":1424947032000},"page":"832-842","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":34,"title":["Daily consumption of white tea (<i>Camellia sinensis<\/i> (L.)) improves the cerebral cortex metabolic and oxidative profile in prediabetic Wistar rats"],"prefix":"10.1017","volume":"113","author":[{"given":"Ana R.","family":"Nunes","sequence":"first","affiliation":[]},{"given":"Marco G.","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Gon\u00e7alo D.","family":"Tom\u00e1s","sequence":"additional","affiliation":[]},{"given":"Vanessa R.","family":"Conde","sequence":"additional","affiliation":[]},{"given":"Ana C.","family":"Crist\u00f3v\u00e3o","sequence":"additional","affiliation":[]},{"given":"Paula I.","family":"Moreira","sequence":"additional","affiliation":[]},{"given":"Pedro F.","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Branca M.","family":"Silva","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2015,2,26]]},"reference":[{"key":"S0007114514004395_ref60","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-41"},{"key":"S0007114514004395_ref56","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600174"},{"key":"S0007114514004395_ref58","first-page":"12","article-title":"Selective neuronal vulnerability to oxidative stress in the brain","volume":"2","author":"Wang","year":"2010","journal-title":"Front Aging Neurosci"},{"key":"S0007114514004395_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.02.072"},{"key":"S0007114514004395_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.02.014"},{"key":"S0007114514004395_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.05.038"},{"key":"S0007114514004395_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.10.011"},{"key":"S0007114514004395_ref52","doi-asserted-by":"publisher","DOI":"10.1021\/jf0006832"},{"key":"S0007114514004395_ref45","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-011-5310-y"},{"key":"S0007114514004395_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.01.075"},{"key":"S0007114514004395_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.02.052"},{"key":"S0007114514004395_ref31","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1248"},{"key":"S0007114514004395_ref32","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.19.326"},{"key":"S0007114514004395_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-013-0640-5"},{"key":"S0007114514004395_ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.08.022"},{"key":"S0007114514004395_ref61","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-44289"},{"key":"S0007114514004395_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem077"},{"key":"S0007114514004395_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00003-007-0250-3"},{"key":"S0007114514004395_ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.06.011"},{"key":"S0007114514004395_ref47","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1640"},{"key":"S0007114514004395_ref35","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-S062"},{"key":"S0007114514004395_ref34","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/19.10.1771"},{"key":"S0007114514004395_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2013.03.005"},{"key":"S0007114514004395_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(90)90208-Q"},{"key":"S0007114514004395_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(02)00169-2"},{"key":"S0007114514004395_ref24","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2009.10718097"},{"key":"S0007114514004395_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1516-3"},{"key":"S0007114514004395_ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.02.040"},{"key":"S0007114514004395_ref16","doi-asserted-by":"publisher","DOI":"10.2174\/2212798410901030182"},{"key":"S0007114514004395_ref8","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7678"},{"key":"S0007114514004395_ref37","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2013.00071.x"},{"key":"S0007114514004395_ref9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.91041.2008"},{"key":"S0007114514004395_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1669-3"},{"key":"S0007114514004395_ref19","doi-asserted-by":"publisher","DOI":"10.1021\/jf4049462"},{"key":"S0007114514004395_ref33","first-page":"83","article-title":"Human salivary tea catechin levels and catechin esterase activities: implication in human cancer prevention studies","volume":"8","author":"Yang","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"S0007114514004395_ref57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01113.2003"},{"key":"S0007114514004395_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2007.10.040"},{"key":"S0007114514004395_ref39","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0292"},{"key":"S0007114514004395_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86141-H"},{"key":"S0007114514004395_ref23","doi-asserted-by":"publisher","DOI":"10.1080\/10408690390826464"},{"key":"S0007114514004395_ref55","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.2067"},{"key":"S0007114514004395_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"S0007114514004395_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2010.07.001"},{"key":"S0007114514004395_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2005.06.005"},{"key":"S0007114514004395_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.10058"},{"key":"S0007114514004395_ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2009.07.004"},{"key":"S0007114514004395_ref63","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200600173"},{"key":"S0007114514004395_ref43","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23320"},{"key":"S0007114514004395_ref50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-8741(02)00217-9","article-title":"Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes","volume":"83","author":"Sabu","year":"2002","journal-title":"J Ethnopharmacol"},{"key":"S0007114514004395_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2007.12.003"},{"key":"S0007114514004395_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60283-9"},{"key":"S0007114514004395_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2013.12.008"},{"key":"S0007114514004395_ref54","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520130111"},{"key":"S0007114514004395_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.01.011"},{"key":"S0007114514004395_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2014.01.006"},{"key":"S0007114514004395_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-010-0203-3"},{"key":"S0007114514004395_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2008.12.003"},{"key":"S0007114514004395_ref17","first-page":"1","article-title":"White tea (Camellia Sinensis (L.)): antioxidant properties and beneficial health effects","volume":"11","author":"Dias","year":"2013","journal-title":"Int J Food Sci Nutr Diet"},{"key":"S0007114514004395_ref51","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1714"},{"key":"S0007114514004395_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.06.017"},{"key":"S0007114514004395_ref40","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.1996.11747079"},{"key":"S0007114514004395_ref36","doi-asserted-by":"publisher","DOI":"10.1007\/BF00873221"},{"key":"S0007114514004395_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1106"},{"key":"S0007114514004395_ref5","doi-asserted-by":"publisher","DOI":"10.2174\/157339912803529896"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114514004395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T02:47:55Z","timestamp":1555814875000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114514004395\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,26]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,3,14]]}},"alternative-id":["S0007114514004395"],"URL":"https:\/\/doi.org\/10.1017\/s0007114514004395","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,26]]},"assertion":[{"value":"Copyright \u00a9 The Authors 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}