{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:26:11Z","timestamp":1772839571067,"version":"3.50.1"},"reference-count":72,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T00:00:00Z","timestamp":1442188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2015,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to evaluate the effects of dietary lipid source and carbohydrate content on the oxidative status of European sea bass (<jats:italic>Dicentrarchus labrax<\/jats:italic>) juveniles. For that purpose, four diets were formulated with fish oil (FO) and vegetable oils (VO) as the lipid source and with 20 or 0 % gelatinised starch as the carbohydrate source, in a 2\u00d72 factorial design. Liver and intestine antioxidant enzyme activities (catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD)), hepatic and intestinal lipid peroxidation (LPO), as well as hepatic oxidative stress index (OSI), were measured in fish fed the experimental diets for 73 d (<jats:italic>n<\/jats:italic>9 fish\/diet). Carbohydrate-rich diets promoted a decrease in hepatic LPO and OSI, whereas the lipid source induced no changes. Inversely, dietary lipid source, but not dietary carbohydrate concentration, affected LPO in the intestine. Lower intestinal LPO was observed in VO groups. Enzymes responsive to dietary treatments were GR, G6PD and CAT in the liver and GR and GPX in the intestine. Dietary carbohydrate induced GR and G6PD activities and depressed CAT activity in the liver. GPX and GR activities were increased in the intestine of fish fed VO diets. Overall, effects of diet composition on oxidative status were tissue-related: the liver and intestine were strongly responsive to dietary carbohydrates and lipid sources, respectively. Furthermore, different metabolic routes were more active to deal with the oxidative stress in the two organs studied.<\/jats:p>","DOI":"10.1017\/s0007114515003360","type":"journal-article","created":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T08:08:32Z","timestamp":1442218112000},"page":"1584-1593","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":61,"title":["Dietary carbohydrate and lipid sources affect differently the oxidative status of European sea bass (<i>Dicentrarchus labrax<\/i>) juveniles"],"prefix":"10.1017","volume":"114","author":[{"given":"Carolina","family":"Castro","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9971-8623","authenticated-orcid":false,"given":"Amalia","family":"Per\u00e9z-Jim\u00e9nez","sequence":"additional","affiliation":[]},{"given":"Filipe","family":"Coutinho","sequence":"additional","affiliation":[]},{"given":"Patricia","family":"D\u00edaz-Rosales","sequence":"additional","affiliation":[]},{"given":"Cl\u00e1udia Alexandra dos Reis","family":"Serra","sequence":"additional","affiliation":[]},{"given":"St\u00e9phane","family":"Panserat","sequence":"additional","affiliation":[]},{"given":"Genevi\u00e8ve","family":"Corraze","sequence":"additional","affiliation":[]},{"given":"Helena","family":"Peres","sequence":"additional","affiliation":[]},{"given":"Aires","family":"Oliva-Teles","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2015,9,14]]},"reference":[{"key":"S0007114515003360_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2095.2009.00721.x"},{"key":"S0007114515003360_ref62","doi-asserted-by":"crossref","unstructured":"Zhao Y , Hu Y , Zhou XQ , et al. (2015) Effects of dietary glutamate supplementation on growth performance, digestive enzyme activities and antioxidant capacity in intestine of grass carp (Ctenopharyngodon idella). Aquac Nutr (epublication ahead of print version 10 January 2015).","DOI":"10.1111\/anu.12215"},{"key":"S0007114515003360_ref31","doi-asserted-by":"publisher","DOI":"10.1111\/anu.12065"},{"key":"S0007114515003360_ref57","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-010-9438-z"},{"key":"S0007114515003360_ref70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.2007.01521.x"},{"key":"S0007114515003360_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2005.09.010"},{"key":"S0007114515003360_ref1","first-page":"304","volume-title":"Nutrient Requirements of Fish","year":"2011"},{"key":"S0007114515003360_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2095.2009.00715.x"},{"key":"S0007114515003360_ref71","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-448"},{"key":"S0007114515003360_ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2012.06.020"},{"key":"S0007114515003360_ref36","volume-title":"Official Methods of Analysis","year":"2000"},{"key":"S0007114515003360_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2010.10.006"},{"key":"S0007114515003360_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2011.10.031"},{"key":"S0007114515003360_ref18","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041165"},{"key":"S0007114515003360_ref49","doi-asserted-by":"crossref","unstructured":"Castro C , Corraze G , P\u00e9rez-Jim\u00e9nez A , et al. (2015) How dietary carbohydrates and lipid source affect lipid and glucose metabolism of European sea bass (Dicentrarchus labrax) juveniles? Br J Nutr (epublication ahead of print version 26 August 2015).","DOI":"10.1017\/S0007114515002731"},{"key":"S0007114515003360_ref68","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2005.03.031"},{"key":"S0007114515003360_ref34","doi-asserted-by":"publisher","DOI":"10.1111\/jwas.12070"},{"key":"S0007114515003360_ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2008.10.009"},{"key":"S0007114515003360_ref37","first-page":"2","volume-title":"Methods of Enzymatic Analysis","author":"Beutler","year":"1984"},{"key":"S0007114515003360_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(90)90014-J"},{"key":"S0007114515003360_ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2009.03.002"},{"key":"S0007114515003360_ref53","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","article-title":"Glutathione metabolism and its implications for health","volume":"134","author":"Wu","year":"2004","journal-title":"J Nutr"},{"key":"S0007114515003360_ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S000711450773461X"},{"key":"S0007114515003360_ref26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S0007114598001330","article-title":"Dietary fish oil and digestible protein modify susceptibility to lipid peroxidation in the muscle of rainbow trout (Oncorhynchus mykiss) and sea bass (Dicentrarchus labrax)","volume":"80","author":"Alvarez","year":"1998","journal-title":"Br J Nutr"},{"key":"S0007114515003360_ref40","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1016\/S0021-9258(18)63504-5","article-title":"Superoxide dismutase: an enzymic function for erythrocuprein","volume":"244","author":"McCord","year":"1969","journal-title":"J Biol Chem"},{"key":"S0007114515003360_ref52","first-page":"521","volume-title":"Lehninger Principles of Biochemistry","author":"Nelson","year":"2004"},{"key":"S0007114515003360_ref54","first-page":"314","article-title":"mRNA expression of antioxidant enzymes (SOD, CAT and GSHPx) and lipid peroxidative stress in liver of Atlantic salmon (Salmo salar) exposed to hyperoxic water during smoltification","volume":"141","author":"Olsvik","year":"2005","journal-title":"Comp Biochem Physiol C"},{"key":"S0007114515003360_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(80)90139-6"},{"key":"S0007114515003360_ref50","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020530432508"},{"key":"S0007114515003360_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(78)52032-6"},{"key":"S0007114515003360_ref51","first-page":"97","article-title":"Glucose: a role as a free radical scavenger in biological systems","volume":"101","author":"Sagone","year":"1983","journal-title":"J Lab Clin Med"},{"key":"S0007114515003360_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2007.08.002"},{"key":"S0007114515003360_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508966071"},{"key":"S0007114515003360_ref28","first-page":"537","article-title":"Antioxidant enzymatic defenses and oxidative damage in Dentex dentex fed on different dietary macronutrient levels","volume":"150","author":"P\u00e9rez-Jim\u00e9nez","year":"2009","journal-title":"Comp Biochem Physiol C"},{"key":"S0007114515003360_ref15","doi-asserted-by":"publisher","DOI":"10.1201\/9781439808634-c14"},{"key":"S0007114515003360_ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2014.07.004"},{"key":"S0007114515003360_ref67","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2011.01.018"},{"key":"S0007114515003360_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0044-8486(03)00537-4"},{"key":"S0007114515003360_ref55","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02320"},{"key":"S0007114515003360_ref39","doi-asserted-by":"crossref","unstructured":"Castro C , Corraze G , Panserat S , et al. (2014) Effects of fish oil replacement by a vegetable oil blend on digestibility, postprandial serum metabolite profile, lipid and glucose metabolism of European sea bass (Dicentrarchus labrax) juveniles. Aquac Nutr (epublication ahead of print version 29 October 2014).","DOI":"10.1111\/anu.12184"},{"key":"S0007114515003360_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.12.004"},{"key":"S0007114515003360_ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-007-9139-4"},{"key":"S0007114515003360_ref16","doi-asserted-by":"crossref","first-page":"715S","DOI":"10.1093\/ajcn\/57.5.715S","article-title":"Lipid peroxidation: its mechanism, measurement, and significance","volume":"57","author":"Halliwell","year":"1993","journal-title":"Am J Clin Nutr"},{"key":"S0007114515003360_ref59","first-page":"1","article-title":"Selected plasma biochemistry parameters in gilthead seabream (Sparus aurata) juveniles","volume":"29","author":"Peres","year":"2012","journal-title":"J Appl Ichthyol"},{"key":"S0007114515003360_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2012.07.003"},{"key":"S0007114515003360_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0044-8486(03)00301-6"},{"key":"S0007114515003360_ref58","first-page":"506","article-title":"The effect of hypoxia on intermediary metabolism and oxidative status in gilthead sea bream (Sparus aurata) fed on diets supplemented with methionine and white tea","volume":"155","author":"P\u00e9rez-Jim\u00e9nez","year":"2012","journal-title":"Comp Biochem Physiol C"},{"key":"S0007114515003360_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2095.2007.00458.x"},{"key":"S0007114515003360_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2014.01.003"},{"key":"S0007114515003360_ref17","doi-asserted-by":"publisher","DOI":"10.1017\/S1357729800058410"},{"key":"S0007114515003360_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)82182-9"},{"key":"S0007114515003360_ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-008-3208-z"},{"key":"S0007114515003360_ref9","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007726615889"},{"key":"S0007114515003360_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2095.2004.00320.x"},{"key":"S0007114515003360_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2014.01.022"},{"key":"S0007114515003360_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2008.01.035"},{"key":"S0007114515003360_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2012.10.030"},{"key":"S0007114515003360_ref42","first-page":"115","article-title":"Assay of glutathione peroxidase","volume":"105","author":"Floh\u00e9","year":"1984","journal-title":"Methods Enzymol"},{"key":"S0007114515003360_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2109.2006.01470.x"},{"key":"S0007114515003360_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"S0007114515003360_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"S0007114515003360_ref13","first-page":"1","article-title":"Transcriptional regulation of cholesterol and bile acid metabolism after dietary soyabean meal treatment in Atlantic salmon (Salmo salar L.)","volume":"30","author":"Kortner","year":"2012","journal-title":"Br J Nutr"},{"key":"S0007114515003360_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0044-8486(01)00852-3"},{"key":"S0007114515003360_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2109.2007.01704.x"},{"key":"S0007114515003360_ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2009.07.028"},{"key":"S0007114515003360_ref47","doi-asserted-by":"publisher","DOI":"10.1007\/BF00755791"},{"key":"S0007114515003360_ref27","doi-asserted-by":"publisher","DOI":"10.2527\/1999.77123322x"},{"key":"S0007114515003360_ref60","doi-asserted-by":"publisher","DOI":"10.1201\/9781439808634-c15"},{"key":"S0007114515003360_ref43","first-page":"153","article-title":"Oxidative stress and antioxidant defenses after prolonged starvation in Dentex dentex liver","volume":"139","author":"Morales","year":"2004","journal-title":"Comp Biochem Physiol C"},{"key":"S0007114515003360_ref65","first-page":"1","article-title":"Antioxidativeaction offlavonoids, quercetin and catechin, mediated by the activation of glutathione peroxidise","volume":"24","author":"Nagata","year":"1999","journal-title":"Tokai J Exp Clin Med"},{"key":"S0007114515003360_ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2005.11.020"},{"key":"S0007114515003360_ref63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058115"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114515003360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T19:27:16Z","timestamp":1653161236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114515003360\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,14]]},"references-count":72,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,11,28]]}},"alternative-id":["S0007114515003360"],"URL":"https:\/\/doi.org\/10.1017\/s0007114515003360","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,14]]},"assertion":[{"value":"Copyright \u00a9 The Authors 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}