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Fish were fed diets including fishmeal (FM diets) or plant feedstuffs (PF diets; 30 FM:70 PF) as main protein sources (control diets). Four other diets were formulated similar to the control diets but including 1 % scFOS or 1 % XOS. At the end of the trial, fish fed PF-based diets presented histomorphological alterations in the distal intestine, whereas only transient alterations were observed in the pyloric caeca. Comparatively to fish fed FM-based diets, fish fed PF diets had higher liver lipid peroxidation (LPO), superoxide dismutase (SOD) and catalase (CAT) activities, and lower glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase activities. In fish fed the PF diets, prebiotic supplementation decreased SOD activity and XOS supplementation further decreased CAT activity. In fish fed the FM diets, XOS supplementation promoted a reduction of all antioxidant enzyme activities. Overall, dietary XOS and scFOS supplementation had only minor effects on gut morphology or LPO levels. However, dietary XOS reduced antioxidant enzymatic activity in both PF and FM diets, which indicate a positive effect on reduction of hepatic reactive oxygen species production.<\/jats:p>","DOI":"10.1017\/s0007114515003773","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T08:12:43Z","timestamp":1444032763000},"page":"1975-1984","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":39,"title":["Gut morphology and hepatic oxidative status of European sea bass (<i>Dicentrarchus labrax<\/i>) juveniles fed plant feedstuffs or fishmeal-based diets supplemented with short-chain fructo-oligosaccharides and xylo-oligosaccharides"],"prefix":"10.1017","volume":"114","author":[{"given":"In\u00eas","family":"Guerreiro","sequence":"first","affiliation":[]},{"given":"Ana","family":"Couto","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9971-8623","authenticated-orcid":false,"given":"Amalia","family":"P\u00e9rez-Jim\u00e9nez","sequence":"additional","affiliation":[]},{"given":"Aires","family":"Oliva-Teles","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Enes","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2015,10,5]]},"reference":[{"key":"S0007114515003773_ref24","doi-asserted-by":"publisher","DOI":"10.1111\/ijfs.12445"},{"key":"S0007114515003773_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2012.06.020"},{"key":"S0007114515003773_ref59","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.6.2.3627"},{"key":"S0007114515003773_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2008.02.013"},{"key":"S0007114515003773_ref52","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1182\/blood.V77.9.2059.2059","article-title":"NADPH, not glutathione, status modulates oxidant sensitivity in normal and glucose-6-phosphate dehydrogenase-deficient erythrocytes","volume":"77","author":"Scott","year":"1991","journal-title":"Blood"},{"key":"S0007114515003773_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2011.07.005"},{"key":"S0007114515003773_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2005.03.031"},{"key":"S0007114515003773_ref1","volume-title":"Demand and Supply of Feed Ingredients for Farmed Fish and Crustaceans. 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