{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T12:53:31Z","timestamp":1696251211243},"reference-count":0,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[2006,7,4]],"date-time":"2006-07-04T00:00:00Z","timestamp":1151971200000},"content-version":"unspecified","delay-in-days":33,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genet. Res."],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p>Weak selection is maintaining the <jats:italic>Drosophila americana X\/4<\/jats:italic> fusion chromosomal frequency cline. The gene(s) harbouring the advantageous variant(s) that is responsible for the establishment and maintenance of this chromosomal frequency gradient must be located in a region of the <jats:italic>X<\/jats:italic> and\/or <jats:italic>4th<\/jats:italic> chromosome that is genetically isolated between the <jats:italic>X\/4<\/jats:italic> fusion and non-fusion forms. The limits of these regions must thus be determined before an attempt is made to identify these genes. For this purpose, the correspondence between the <jats:italic>D. virilis X<\/jats:italic> and <jats:italic>4th<\/jats:italic> chromosome genome scaffolds sequence and the <jats:italic>D. americana<\/jats:italic> gene order was established. Polymorphism levels and patterns at seven genes located at the base of the <jats:italic>D. americana X<\/jats:italic> chromosome, as well as three genes located at the base of the <jats:italic>4th<\/jats:italic> chromosome, were analysed. The data suggest that the <jats:italic>D. americana X\/4<\/jats:italic> fusion is no more than 29000 years old. At the base of the <jats:italic>X<\/jats:italic> chromosome, there is suppression of recombination within <jats:italic>X\/4<\/jats:italic> fusion and non-fusion chromosomes, and little recombination between the two chromosomal forms. Apparent fixed silent and replacement differences are found in three of seven genes analysed located at the base of the <jats:italic>X<\/jats:italic> chromosome. There is no evidence for suppression of recombination between fusion and non-fusion chromosomes at the base of the <jats:italic>4th<\/jats:italic> chromosome. The advantageous variant responsible for the establishment in frequency and maintenance of the <jats:italic>X\/4<\/jats:italic> fusion is thus inferred to be in the <jats:italic>D. americana X<\/jats:italic> centromere\u2013inversion <jats:italic>Xc<\/jats:italic> basal breakpoint region.<\/jats:p>","DOI":"10.1017\/s0016672306008147","type":"journal-article","created":{"date-parts":[[2006,7,5]],"date-time":"2006-07-05T22:54:39Z","timestamp":1152140079000},"page":"163-174","source":"Crossref","is-referenced-by-count":14,"title":["On the location of the gene(s) harbouring the advantageous variant that maintains the <i>X\/4<\/i> fusion of <i>Drosophila americana<\/i>"],"prefix":"10.1155","volume":"87","author":[{"given":"CRISTINA P.","family":"VIEIRA","sequence":"first","affiliation":[]},{"given":"ANDR\u00c9","family":"ALMEIDA","sequence":"additional","affiliation":[]},{"given":"JO\u00c3O","family":"DANIEL DIAS","sequence":"additional","affiliation":[]},{"given":"JORGE","family":"VIEIRA","sequence":"additional","affiliation":[]}],"member":"98","published-online":{"date-parts":[[2006,7,4]]},"container-title":["Genetical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0016672306008147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T22:47:27Z","timestamp":1609454847000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0016672306008147\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0016672306008147"],"URL":"https:\/\/doi.org\/10.1017\/s0016672306008147","relation":{},"ISSN":["0016-6723","1469-5073"],"issn-type":[{"value":"0016-6723","type":"print"},{"value":"1469-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}